RHOA Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis. May be an activator of PLCE1. In neurons, involved in the inhibiton of the initial spine growth. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling. (Microbial infection) Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague. Belongs to the small GTPase superfamily. Rho family. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of Human Ortholog: 9|9 F1-F2
Cellular Component:  apical junction complex; axon; cell cortex; cell division site; cell periphery; cell projection; cytoplasm; cytoskeleton; cytosol; dendritic spine; endosome; extrinsic component of cytoplasmic side of plasma membrane; glutamatergic synapse; intracellular membrane-bounded organelle; lamellipodium; membrane; nucleus; plasma membrane; postsynapse; ruffle membrane; vesicle
Molecular Function:  GDP binding; GTP binding; GTPase activity; myosin binding; nucleotide binding; protein binding; protein domain specific binding; protein kinase binding; Rho GDP-dissociation inhibitor binding
Biological Process:  actin cytoskeleton organization; actin cytoskeleton reorganization; actin filament bundle assembly; actin filament organization; alpha-beta T cell lineage commitment; androgen receptor signaling pathway; angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure; apical junction assembly; apolipoprotein A-I-mediated signaling pathway; beta selection; cell adhesion; cell cycle; cell differentiation; cell division; cell junction assembly; cell migration; cell morphogenesis; cell-matrix adhesion; cellular response to chemokine; cellular response to cytokine stimulus; cellular response to lipopolysaccharide; cerebral cortex cell migration; cleavage furrow formation; cytoskeleton organization; endothelial cell migration; endothelial tube lumen extension; establishment of epithelial cell apical/basal polarity; establishment or maintenance of actin cytoskeleton polarity; forebrain radial glial cell differentiation; GTP metabolic process; integrin-mediated signaling pathway; mitotic cleavage furrow formation; mitotic spindle assembly; negative chemotaxis; negative regulation of cell death; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of cell size; negative regulation of cell-substrate adhesion; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of intracellular steroid hormone receptor signaling pathway; negative regulation of neuron apoptotic process; negative regulation of neuron differentiation; negative regulation of neuron projection development; negative regulation of oxidative phosphorylation; negative regulation of reactive oxygen species biosynthetic process; odontogenesis; ossification involved in bone maturation; positive regulation of actin filament polymerization; positive regulation of alpha-beta T cell differentiation; positive regulation of cell growth; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of cytokinesis; positive regulation of leukocyte adhesion to vascular endothelial cell; positive regulation of lipase activity; positive regulation of neuron apoptotic process; positive regulation of neuron differentiation; positive regulation of NIK/NF-kappaB signaling; positive regulation of podosome assembly; positive regulation of protein serine/threonine kinase activity; positive regulation of smooth muscle contraction; positive regulation of stress fiber assembly; positive regulation of T cell migration; positive regulation of vascular smooth muscle contraction; regulation of actin cytoskeleton organization; regulation of calcium ion transport; regulation of cell migration; regulation of cell shape; regulation of dendrite development; regulation of microtubule cytoskeleton organization; regulation of modification of postsynaptic actin cytoskeleton; regulation of modification of synaptic structure; regulation of neural precursor cell proliferation; regulation of neuron projection development; regulation of osteoblast proliferation; regulation of systemic arterial blood pressure by endothelin; regulation of transcription by RNA polymerase II; response to drug; Rho protein signal transduction; Roundabout signaling pathway; skeletal muscle tissue development; small GTPase mediated signal transduction; stress fiber assembly; stress-activated protein kinase signaling cascade; trabecula morphogenesis
Reference #:  Q9QUI0 (UniProtKB)
Alt. Names/Synonyms: aplysia ras-related homolog A; aplysia ras-related homolog A1; aplysia ras-related homolog A2; Arha; Arha1; Arha2; ras homolog A1; ras homolog A2; ras homolog family member A; ras homolog gene family, member A; ras homolog gene family, member A1; ras homolog gene family, member A2; Rho family GTPase; Rhoa; Transforming protein RhoA
Gene Symbols: Rhoa
Molecular weight: 21,782 Da
Basal Isoelectric point: 5.83  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  B Cell Receptor Signaling  |  Microtubule Dynamics  |  SAPK/JNK Signaling Cascades  |  TGF-ß Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene