|
RHOB
Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells. Belongs to the small GTPase superfamily. Rho family. Note: This description may include information from UniProtKB.
|
| Protein type: G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis; Tumor suppressor |
| Chromosomal Location of Human Ortholog: 12|12 A1.1 |
|
Cellular Component:
cell cortex; cell division site; cleavage furrow; cytoplasm; cytosol; early endosome; endosome; endosome membrane; intracellular membrane-bounded organelle; late endosome; membrane; nucleus; plasma membrane
|
|
Molecular Function:
GDP binding; GTP binding; GTPase activity; nucleotide binding; protein binding; protein kinase binding
|
|
Biological Process:
actin filament bundle assembly; actin filament organization; angiogenesis; apoptotic process; cell adhesion; cell differentiation; cell migration; cellular response to hydrogen peroxide; cellular response to ionizing radiation; endosome to lysosome transport; endothelial tube morphogenesis; establishment or maintenance of actin cytoskeleton polarity; intracellular protein transport; mitotic cytokinesis; multicellular organism development; negative regulation of cell cycle; negative regulation of cell migration; positive regulation of angiogenesis; positive regulation of apoptotic process; positive regulation of endothelial cell migration; protein transport; regulation of actin cytoskeleton organization; regulation of cell migration; regulation of cell shape; Rho protein signal transduction; small GTPase mediated signal transduction
|
|
Reference #:
P62746
(UniProtKB)
|
|
Alt. Names/Synonyms: AA017882; aplysia ras-related homolog B; Arh6; Arhb; MGC117867; ras homolog B; ras homolog gene family, member AB; ras homolog gene family, member B; Rho-related GTP-binding protein RhoB; Rhob
|
|
Gene Symbols: Rhob
|
|
Molecular weight:
22,123 Da
|
|
Basal Isoelectric point:
5.1
Predict pI for various phosphorylation states
|
|
CST Pathways:
Actin Dynamics
|
Microtubule Dynamics
|
SAPK/JNK Signaling Cascades
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
