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RHOB
Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells. Belongs to the small GTPase superfamily. Rho family. Note: This description may include information from UniProtKB.
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| Protein type: G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis; Tumor suppressor |
| Chromosomal Location of mouse Ortholog: 12|12 A1.1 |
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Cellular Component:
cleavage furrow; cytosol; early endosome; endosome; endosome membrane; late endosome; membrane; nucleus; plasma membrane; Schaffer collateral - CA1 synapse; synapse
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Molecular Function:
GDP binding; GTP binding; GTPase activity; nucleotide binding; protein binding
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Biological Process:
actin filament organization; angiogenesis; apoptotic process; cell adhesion; cell differentiation; cellular response to hydrogen peroxide; cellular response to ionizing radiation; endosome to lysosome transport; endothelial tube morphogenesis; intracellular protein transport; mitotic cytokinesis; multicellular organism development; negative regulation of cell cycle; negative regulation of cell migration; positive regulation of angiogenesis; positive regulation of apoptotic process; positive regulation of endothelial cell migration; protein transport; regulation of cell migration; regulation of modification of postsynaptic structure; signal transduction; small GTPase mediated signal transduction
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Reference #:
P62746
(UniProtKB)
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Alt. Names/Synonyms: AA017882; aplysia ras-related homolog B; Arh6; Arhb; MGC117867; ras homolog B; ras homolog family member B; ras homolog gene family, member AB; ras homolog gene family, member B; Rho-related GTP-binding protein RhoB; Rhob
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Gene Symbols: Rhob
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Molecular weight:
22,123 Da
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Basal Isoelectric point:
5.1
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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Microtubule Dynamics
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SAPK/JNK Signaling Cascades
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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