|
ROR2
Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation. In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling. Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. Note: This description may include information from UniProtKB.
|
| Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); Ror family; TK group |
| Chromosomal Location of mouse Ortholog: 13 B1|13 27.68 cM |
|
Cellular Component:
cell surface; dendrite; glutamatergic synapse; membrane; microtubule; neuronal cell body; plasma membrane; postsynapse; receptor complex
|
|
Molecular Function:
ATP binding; frizzled binding; kinase activity; metal ion binding; mitogen-activated protein kinase kinase kinase binding; nucleotide binding; protein binding; protein kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity; Wnt-protein binding
|
|
Biological Process:
astrocyte development; BMP signaling pathway; cartilage condensation; cell fate commitment; chondrocyte differentiation; embryonic digit morphogenesis; embryonic genitalia morphogenesis; inner ear morphogenesis; JNK cascade; macrophage migration; modulation of chemical synaptic transmission; multicellular organism development; negative regulation of canonical Wnt signaling pathway; phosphorylation; positive regulation of canonical Wnt signaling pathway; positive regulation of cell migration; positive regulation of DNA-templated transcription; positive regulation of ERK1 and ERK2 cascade; positive regulation of JUN kinase activity; positive regulation of kinase activity; positive regulation of macrophage differentiation; positive regulation of neuron projection development; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein kinase C activity; positive regulation of synaptic transmission, glutamatergic; protein phosphorylation; regulation of canonical Wnt signaling pathway; regulation of postsynapse organization; regulation of synaptic signaling by nitric oxide; signal transduction; skeletal system development; SMAD protein signal transduction; smoothened signaling pathway; somitogenesis; transmembrane receptor protein tyrosine kinase signaling pathway; Wnt signaling pathway; Wnt signaling pathway, calcium modulating pathway; Wnt signaling pathway, planar cell polarity pathway
|
|
Reference #:
Q9Z138
(UniProtKB)
|
|
Alt. Names/Synonyms: mROR2; neurotrophic tyrosine kinase, receptor related 2; Neurotrophic tyrosine kinase, receptor-related 2; Ntr; Ntrkr2; receptor tyrosine kinase-like orphan receptor 2; Ror2; Tyrosine-protein kinase transmembrane receptor ROR2
|
|
Gene Symbols: Ror2
|
|
Molecular weight:
105,005 Da
|
|
Basal Isoelectric point:
6.03
Predict pI for various phosphorylation states
|
|
CST Pathways:
Tyrosine Kinases & Substrates
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
