MKL1
Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. Ubiquitously expressed, has been detected in lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, muscle, heart and brain. Note: This description may include information from UniProtKB.
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Protein type: Oncoprotein; Transcription, coactivator/corepressor |
Chromosomal Location of mouse Ortholog: 15|15 E1 |
Cellular Component:
cytoplasm; cytosol; nucleoplasm; nucleus
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Molecular Function:
actin binding; actin monomer binding; DNA-binding transcription factor activity; leucine zipper domain binding; molecular adaptor activity; protein binding; transcription cis-regulatory region binding; transcription coactivator activity
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Biological Process:
actin cytoskeleton organization; forebrain development; negative regulation of apoptotic signaling pathway; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; neuron migration; neuron projection development; positive regulation of DNA-templated transcription; positive regulation of miRNA transcription; positive regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; smooth muscle cell differentiation; wound healing, spreading of cells
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Reference #:
Q8K4J6
(UniProtKB)
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Alt. Names/Synonyms: AI852829; AMKL; AW743281; AW821984; basic SAP and coiled-coil domains; Basic SAP coiled-coil transcription activator; Bsac; Mal; megakaryoblastic leukemia (translocation) 1 homolog; Megakaryoblastic leukemia 1 protein homolog; Megakaryocytic acute leukemia protein homolog; Mkl; MKL (megakaryoblastic leukemia)/myocardin-like 1; MKL/myocardin-like protein 1; Mkl1; MRTF; MRTF-A; Mrtfa; myocardial related transcription factor A; myocardin related transcription factor A; Myocardin-related transcription factor A
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Gene Symbols: Mrtfa
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Molecular weight:
102,546 Da
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Basal Isoelectric point:
5.35
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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