Ezrin a member of the ERM family which includes radixin and moesin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Plays a key role in cell surface structure adhesion, migration, and organization. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17|17 A1
Cellular Component:  actin cytoskeleton; actin filament; apical part of cell; apical plasma membrane; astrocyte projection; basolateral plasma membrane; brush border; cell body; cell periphery; cell projection; cell tip; ciliary basal body; cytoplasm; cytoplasmic side of apical plasma membrane; cytoskeleton; cytosol; endosome; extrinsic component of membrane; fibrillar center; filopodium; immunological synapse; invadopodium; membrane; membrane raft; microspike; microvillus; microvillus membrane; perinuclear region of cytoplasm; plasma membrane; plasma membrane raft; protein-containing complex; ruffle; Schwann cell microvillus; T-tubule; uropod
Molecular Function:  actin binding; actin filament binding; ATPase binding; cell adhesion molecule binding; cytoskeletal protein binding; disordered domain specific binding; identical protein binding; microtubule binding; protein binding; protein C-terminus binding; protein domain specific binding; protein kinase A binding; protein kinase A catalytic subunit binding; protein kinase A regulatory subunit binding; protein-containing complex binding; S100 protein binding
Biological Process:  actin cytoskeleton reorganization; actin filament bundle assembly; astral microtubule organization; cellular protein-containing complex localization; cellular response to cAMP; cortical microtubule organization; establishment of centrosome localization; establishment of endothelial barrier; establishment or maintenance of apical/basal cell polarity; filopodium assembly; intestinal D-glucose absorption; negative regulation of ERK1 and ERK2 cascade; negative regulation of interleukin-2 secretion; negative regulation of p38MAPK cascade; negative regulation of T cell receptor signaling pathway; negative regulation of transcription by RNA polymerase II; phosphatidylinositol-mediated signaling; positive regulation of cellular protein catabolic process; positive regulation of early endosome to late endosome transport; positive regulation of gene expression; positive regulation of multicellular organism growth; positive regulation of protein localization to early endosome; positive regulation of protein localization to plasma membrane; positive regulation of protein secretion; protein kinase A signaling; protein localization to cell cortex; protein localization to plasma membrane; receptor internalization; regulation of cell shape; regulation of microvillus length; regulation of organelle assembly; sphingosine-1-phosphate receptor signaling pathway; terminal web assembly
Reference #:  P26040 (UniProtKB)
Alt. Names/Synonyms: AW146364; Cytovillin; Ezr; EZRI; Ezrin; MGC107499; OTTMUSP00000019758; p81; R75297; Vil2; villin 2; Villin-2
Gene Symbols: Ezr
Molecular weight: 69,407 Da
Basal Isoelectric point: 5.83  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene