Ets-2 Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription. Belongs to the ETS family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 16 C4|16 56.64 cM
Cellular Component:  cytosol; nucleoplasm; nucleus; plasma membrane
Molecular Function:  DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; glucocorticoid receptor binding; protein domain specific binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding
Biological Process:  cell differentiation; ectodermal cell fate commitment; mesoderm development; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; primitive streak formation; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated
Reference #:  P15037 (UniProtKB)
Alt. Names/Synonyms: AU022856; E26 avian leukemia oncogene 2, 3' domain; Ets-; Ets-2; Ets2; Protein C-ets-2
Gene Symbols: Ets2
Molecular weight: 52,827 Da
Basal Isoelectric point: 4.96  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene