ORAI1 Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. Belongs to the Orai family. 2 alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of mouse Ortholog: 5|5 F
Cellular Component:  basolateral plasma membrane; cytoplasmic vesicle; cytosol; growth cone; integral component of membrane; integral component of plasma membrane; membrane; membrane raft; plasma membrane; plasma membrane raft; protein-containing complex
Molecular Function:  calcium channel activity; calmodulin binding; identical protein binding; protein binding; store-operated calcium channel activity
Biological Process:  adaptive immune response; calcium ion import; calcium ion transmembrane transport; calcium ion transport; immune system process; ion transport; mammary gland epithelium development; positive regulation of adenylate cyclase activity; positive regulation of calcium ion transport; regulation of calcium ion transport; store-operated calcium entry
Reference #:  Q8BWG9 (UniProtKB)
Alt. Names/Synonyms: calcium release-activated calcium channel 1; Calcium release-activated calcium channel protein 1; Cracm1; CRCM1; D730049H07Rik; ORAI calcium release-activated calcium modulator 1; orai-1; Orai1; Protein orai-1; Tmem142; Tmem142a; Transmembrane protein 142A
Gene Symbols: Orai1
Molecular weight: 33,062 Da
Basal Isoelectric point: 6.56  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  T Cell Receptor Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene