CRHR2 G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Belongs to the G-protein coupled receptor 2 family. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of human Ortholog: 7p14.3
Cellular Component:  axon terminus; dendrite; plasma membrane
Molecular Function:  corticotrophin-releasing factor receptor activity; corticotropin-releasing hormone receptor activity; G protein-coupled peptide receptor activity; peptide hormone binding; protein binding
Biological Process:  adenylate cyclase-modulating G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; cellular response to corticotropin-releasing hormone stimulus; hormone-mediated signaling pathway; long-term synaptic potentiation
Reference #:  Q13324 (UniProtKB)
Alt. Names/Synonyms: corticotropin releasing hormone receptor 2; Corticotropin-releasing factor receptor 2; Corticotropin-releasing hormone receptor 2; CRF-R-2; CRF-R2; CRF-RB; CRF2; CRF2R; CRFR-2; CRFR2; CRH receptor 2 variant B; CRH-R-2; CRH-R2; CRH2R; CRHR2; HM-CRF
Gene Symbols: CRHR2
Molecular weight: 47,688 Da
Basal Isoelectric point: 7.87  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein