|
CRHR2
G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Belongs to the G-protein coupled receptor 2 family. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of human Ortholog: 7p14.3 |
|
Cellular Component:
axon terminus; dendrite; plasma membrane
|
|
Molecular Function:
corticotrophin-releasing factor receptor activity; corticotropin-releasing hormone receptor activity; G protein-coupled peptide receptor activity; peptide hormone binding; protein binding
|
|
Biological Process:
adenylate cyclase-modulating G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; cellular response to corticotropin-releasing hormone stimulus; hormone-mediated signaling pathway; long-term synaptic potentiation
|
|
Reference #:
Q13324
(UniProtKB)
|
|
Alt. Names/Synonyms: corticotropin releasing hormone receptor 2; Corticotropin-releasing factor receptor 2; Corticotropin-releasing hormone receptor 2; CRF-R-2; CRF-R2; CRF-RB; CRF2; CRF2R; CRFR-2; CRFR2; CRH receptor 2 variant B; CRH-R-2; CRH-R2; CRH2R; CRHR2; HM-CRF
|
|
Gene Symbols: CRHR2
|
|
Molecular weight:
47,688 Da
|
|
Basal Isoelectric point:
7.87
Predict pI for various phosphorylation states
|
