ERK5 Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. Expressed in many adult tissues. Abundant in heart, placenta, lung, kidney and skeletal muscle. Not detectable in liver. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CMGC group; EC 2.7.11.24; ERK subfamily; Kinase, protein; MAPK family; MAPK/ERK subfamily; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 11|11 B2
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus; PML body
Molecular Function:  ATP binding; kinase activity; MAP kinase activity; mitogen-activated protein kinase binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  cell cycle; cell differentiation; cellular response to growth factor stimulus; cellular response to hydrogen peroxide; cellular response to laminar fluid shear stress; cellular response to organic substance; cellular response to transforming growth factor beta stimulus; intracellular signal transduction; negative regulation of apoptotic process; negative regulation of calcineurin-NFAT signaling cascade; negative regulation of endothelial cell apoptotic process; negative regulation of ERK5 cascade; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of heterotypic cell-cell adhesion; negative regulation of MAP kinase activity; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; negative regulation of response to cytokine stimulus; peptidyl-serine phosphorylation; phosphorylation; positive regulation of protein metabolic process; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to stress; protein phosphorylation; regulation of angiogenesis; regulation of gene expression
Reference #:  Q9WVS8 (UniProtKB)
Alt. Names/Synonyms: b2b2346C; b2b2346Clo; Big MAP kinase 1; BMK-1; Bmk1; ERK; ERK-5; Erk5; Erk5-; Erk5-T; extracellular signal regulated kinase 5; Extracellular signal-regulated kinase 5; MAP kinase 7; MAPK 7; Mapk7; mitogen activated protein kinase 7; mitogen-activated kinase 7; Mitogen-activated protein kinase 7; MK07; OTTMUSP00000006027; PRKM7
Gene Symbols: Mapk7
Molecular weight: 87,733 Da
Basal Isoelectric point: 5.52  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  IL6 Signaling  |  Microtubule Dynamics  |  mTOR Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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ERK5

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Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene