ERK3 Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts. Note: This description may include information from UniProtKB.
Protein type: CMGC group; EC 2.7.11.24; ERK subfamily; Kinase, protein; MAPK family; MAPK/ERK subfamily; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 8q24
Cellular Component:  cytoplasm; cytosol; nucleus; protein-containing complex; septin cytoskeleton
Molecular Function:  ATP binding; MAP kinase activity; protein heterodimerization activity; protein kinase activity; protein kinase binding
Biological Process:  cellular response to organic substance; intracellular signal transduction; MAPK cascade; positive regulation of dendritic spine development; protein phosphorylation; regulation of gene expression
Reference #:  P27704 (UniProtKB)
Alt. Names/Synonyms: ERK-3; Erk3; Extracellular signal-regulated kinase 3; MAP kinase 6; MAPK 6; Mapk6; MGC124957; Mitogen-activated protein kinase 6; MK06; p55-MAPK; Prkm6
Gene Symbols: Mapk6
Molecular weight: 82,275 Da
Basal Isoelectric point: 5.04  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  IL6 Signaling  |  Microtubule Dynamics  |  mTOR Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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ERK3

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene