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ERK3
Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts. Note: This description may include information from UniProtKB.
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| Protein type: CMGC group; EC 2.7.11.24; ERK subfamily; Kinase, protein; MAPK family; MAPK/ERK subfamily; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of mouse Ortholog: 9 D|9 42.3 cM |
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Cellular Component:
cytoplasm; cytosol; nucleus; protein-containing complex; septin cytoskeleton
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Molecular Function:
ATP binding; kinase activity; MAP kinase activity; nucleotide binding; protein binding; protein heterodimerization activity; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; transferase activity
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Biological Process:
cell cycle; cellular response to organic substance; intracellular signal transduction; phosphorylation; positive regulation of dendritic spine development; protein phosphorylation; regulation of gene expression
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Reference #:
Q61532
(UniProtKB)
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Alt. Names/Synonyms: 2610021I23Rik; D130053K17Rik; ERK; ERK-3; Erk-3 related; Erk3; Extracellular signal-regulated kinase 3; Map; MAP kinase 6; Mapk; MAPK 6; Mapk4; Mapk6; Mapk63; mitogen activated protein kinase 4; mitogen activated protein kinase 6; Mitogen-activated protein kinase 6; MK06; Prk; Prkm4; Prkm6; protein kinase, mitogen activated kinase 4
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Gene Symbols: Mapk6
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Molecular weight:
82,199 Da
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Basal Isoelectric point:
5.05
Predict pI for various phosphorylation states
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CST Pathways:
ErbB/HER Signaling
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GPCR Signaling to MAPKs
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IL6 Signaling
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Microtubule Dynamics
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mTOR Signaling
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Translation: eIF4E and p70S6K
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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