ERK3 Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts. Note: This description may include information from UniProtKB.
Protein type: CMGC group; EC; ERK subfamily; Kinase, protein; MAPK family; MAPK/ERK subfamily; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of mouse Ortholog: 9 D|9 42.3 cM
Cellular Component:  cytoplasm; cytosol; nucleus; protein-containing complex; septin cytoskeleton
Molecular Function:  ATP binding; kinase activity; MAP kinase activity; nucleotide binding; protein binding; protein heterodimerization activity; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; transferase activity
Biological Process:  cell cycle; cellular response to organic substance; intracellular signal transduction; phosphorylation; positive regulation of dendritic spine development; protein phosphorylation; regulation of gene expression
Reference #:  Q61532 (UniProtKB)
Alt. Names/Synonyms: 2610021I23Rik; D130053K17Rik; ERK; ERK-3; Erk-3 related; Erk3; Extracellular signal-regulated kinase 3; Map; MAP kinase 6; Mapk; MAPK 6; Mapk4; Mapk6; Mapk63; mitogen activated protein kinase 4; mitogen activated protein kinase 6; Mitogen-activated protein kinase 6; MK06; Prk; Prkm4; Prkm6; protein kinase, mitogen activated kinase 4
Gene Symbols: Mapk6
Molecular weight: 82,199 Da
Basal Isoelectric point: 5.05  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  IL6 Signaling  |  Microtubule Dynamics  |  mTOR Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene