HER2 Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth. 6 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; EGFR family; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of mouse Ortholog: 11 61.75 cM|11 D
Cellular Component:  apical plasma membrane; basal plasma membrane; basolateral plasma membrane; cytoplasm; cytoplasmic vesicle; cytosol; endosome; endosome membrane; ERBB3:ERBB2 complex; lateral loop; membrane; membrane raft; microvillus; myelin sheath; neuromuscular junction; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic membrane; presynaptic membrane; receptor complex
Molecular Function:  ATP binding; ErbB-3 class receptor binding; growth factor binding; Hsp90 protein binding; identical protein binding; kinase activity; nucleotide binding; protein binding; protein C-terminus binding; protein heterodimerization activity; protein kinase activity; protein phosphatase binding; protein tyrosine kinase activity; protein-containing complex binding; RNA polymerase I core binding; transferase activity; transmembrane receptor protein tyrosine kinase activity; transmembrane signaling receptor activity; ubiquitin protein ligase binding
Biological Process:  cell surface receptor signaling pathway; cellular response to epidermal growth factor stimulus; cellular response to growth factor stimulus; ERBB2-EGFR signaling pathway; ERBB2-ERBB3 signaling pathway; ERBB2-ERBB4 signaling pathway; estrous cycle; glial cell differentiation; heart development; immature T cell proliferation in thymus; intracellular signal transduction; motor neuron axon guidance; multicellular organism development; myelination; negative regulation of apoptotic process; negative regulation of immature T cell proliferation in thymus; nervous system development; neuromuscular junction development; neuron differentiation; neurotransmitter receptor localization to postsynaptic specialization membrane; oligodendrocyte differentiation; peptidyl-tyrosine phosphorylation; peripheral nervous system development; phosphatidylinositol 3-kinase signaling; phosphorylation; positive regulation of cell adhesion; positive regulation of cell growth; positive regulation of cell population proliferation; positive regulation of epithelial cell proliferation; positive regulation of gene expression; positive regulation of GTPase activity; positive regulation of kinase activity; positive regulation of MAP kinase activity; positive regulation of MAPK cascade; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein phosphorylation; positive regulation of protein targeting to membrane; positive regulation of Ras protein signal transduction; positive regulation of transcription by RNA polymerase I; positive regulation of translation; protein autophosphorylation; protein phosphorylation; regulation of ERK1 and ERK2 cascade; regulation of microtubule-based process; response to axon injury; signal transduction; sympathetic nervous system development; transmembrane receptor protein tyrosine kinase signaling pathway; wound healing
Reference #:  P70424 (UniProtKB)
Alt. Names/Synonyms: avian erythroblastosis oncogene B 2; c-erbB; c-erbB-2; c-erbB2; c-ne; c-neu; CD340; erb-b2 receptor tyrosine kinase 2; ErbB-; Erbb-2; Erbb2; HER; HER-; HER-2; HER2; Kiaa3023; l11Ju; l11Jus8; mKIAA3023; Neu; Neu oncogene; OTTMUSP00000002540; p185erbB2; Proto-oncogene c-ErbB-2; Proto-oncogene Neu; Receptor tyrosine-protein kinase erbB-2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Gene Symbols: Erbb2
Molecular weight: 138,579 Da
Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene