HER2 Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth. 6 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; EGFR family; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 17q12
Cellular Component:  apical plasma membrane; basolateral plasma membrane; cytosol; endosome membrane; integral component of membrane; myelin sheath; nucleus; perinuclear region of cytoplasm; plasma membrane; receptor complex
Molecular Function:  ATP binding; ErbB-3 class receptor binding; identical protein binding; protein binding; protein C-terminus binding; protein dimerization activity; protein heterodimerization activity; protein phosphatase binding; protein tyrosine kinase activity; RNA polymerase I core binding; transmembrane receptor protein tyrosine kinase activity; transmembrane signaling receptor activity
Biological Process:  cell surface receptor signaling pathway; cellular response to epidermal growth factor stimulus; cellular response to growth factor stimulus; enzyme linked receptor protein signaling pathway; ERBB2 signaling pathway; heart development; intracellular signal transduction; MAPK cascade; motor neuron axon guidance; myelination; negative regulation of ERBB signaling pathway; negative regulation of immature T cell proliferation in thymus; neuromuscular junction development; oligodendrocyte differentiation; peptidyl-tyrosine phosphorylation; peripheral nervous system development; phosphatidylinositol 3-kinase signaling; positive regulation of cell adhesion; positive regulation of cell growth; positive regulation of epithelial cell proliferation; positive regulation of GTPase activity; positive regulation of MAP kinase activity; positive regulation of protein kinase B signaling; positive regulation of protein phosphorylation; positive regulation of protein targeting to membrane; positive regulation of transcription by RNA polymerase I; positive regulation of translation; protein autophosphorylation; protein phosphorylation; regulation of angiogenesis; regulation of cell motility; regulation of ERK1 and ERK2 cascade; regulation of microtubule-based process; regulation of transcription by RNA polymerase II; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; wound healing
Disease: Gastric Cancer; Glioma Susceptibility 1; Lung Cancer
Reference #:  P04626 (UniProtKB)
Alt. Names/Synonyms: c-erb B2/neu protein; CD340; erbB-2; ERBB2; HER-2; HER-2/neu; HER2; herstatin; Metastatic lymph node gene 19 protein; MLN 19; MLN19; NEU; neuroblastoma/glioblastoma derived oncogene homolog; NGL; p185erbB2; Proto-oncogene c-ErbB-2; Proto-oncogene Neu; Receptor tyrosine-protein kinase erbB-2; TKR1; Tyrosine kinase-type cell surface receptor HER2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog); v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Gene Symbols: ERBB2
Molecular weight: 137,910 Da
Basal Isoelectric point: 5.58  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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HER2

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