GABRG3 GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG3 sub-subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of human Ortholog: 15q12
Cellular Component:  chloride channel complex; dendrite membrane; GABA-A receptor complex; GABA-ergic synapse; neuron projection; plasma membrane; postsynapse; postsynaptic membrane; synapse
Molecular Function:  benzodiazepine receptor activity; chloride channel activity; excitatory extracellular ligand-gated ion channel activity; GABA-A receptor activity; GABA-gated chloride ion channel activity; inhibitory extracellular ligand-gated ion channel activity; neurotransmitter receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
Biological Process:  chemical synaptic transmission; chloride transmembrane transport; excitatory postsynaptic potential; gamma-aminobutyric acid signaling pathway; ion transmembrane transport; nervous system process; regulation of membrane potential; regulation of postsynaptic membrane potential; response to xenobiotic stimulus; signal transduction; synaptic transmission, GABAergic
Reference #:  Q99928 (UniProtKB)
Alt. Names/Synonyms: GABA(A) receptor subunit gamma-3; GABA(G) receptor, gamma 3; GABRG3; gamma-aminobutyric acid (GABA) A receptor, gamma 3; Gamma-aminobutyric acid receptor subunit gamma-3; gamma-aminobutyric acid type A receptor gamma3 subunit; gamma-aminobutyric acid type A receptor subunit gamma3; GBRG3
Gene Symbols: GABRG3
Molecular weight: 54,289 Da
Basal Isoelectric point: 7.46  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB