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GABRG3
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG3 sub-subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel |
| Chromosomal Location of human Ortholog: 15q12 |
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Cellular Component:
chloride channel complex; dendrite membrane; GABA-A receptor complex; GABA-ergic synapse; neuron projection; plasma membrane; postsynapse; postsynaptic membrane; synapse
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Molecular Function:
benzodiazepine receptor activity; chloride channel activity; excitatory extracellular ligand-gated ion channel activity; GABA-A receptor activity; GABA-gated chloride ion channel activity; inhibitory extracellular ligand-gated ion channel activity; neurotransmitter receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
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Biological Process:
chemical synaptic transmission; chloride transmembrane transport; excitatory postsynaptic potential; gamma-aminobutyric acid signaling pathway; ion transmembrane transport; nervous system process; regulation of membrane potential; regulation of postsynaptic membrane potential; response to xenobiotic stimulus; signal transduction; synaptic transmission, GABAergic
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Reference #:
Q99928
(UniProtKB)
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Alt. Names/Synonyms: GABA(A) receptor subunit gamma-3; GABA(G) receptor, gamma 3; GABRG3; gamma-aminobutyric acid (GABA) A receptor, gamma 3; Gamma-aminobutyric acid receptor subunit gamma-3; gamma-aminobutyric acid type A receptor gamma3 subunit; gamma-aminobutyric acid type A receptor subunit gamma3; GBRG3
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Gene Symbols: GABRG3
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Molecular weight:
54,289 Da
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Basal Isoelectric point:
7.46
Predict pI for various phosphorylation states
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