ER-beta Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual. Belongs to the nuclear hormone receptor family. NR3 subfamily. Isoform 1 is expressed in testis and ovary, and at a lower level in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, prostate, colon, bone marrow, mammary gland and uterus. Also found in uterine bone, breast, and ovarian tumor cell lines, but not in colon and liver tumors. Isoform 2 is expressed in spleen, thymus, testis and ovary and at a lower level in skeletal muscle, prostate, colon, small intestine, leukocytes, bone marrow, mammary gland and uterus. Isoform 4 is found in testis. Isoform 5 is expressed in testis, and at a lower level in spleen, thymus, ovary, mammary gland and uterus. Isoform 6 is expressed in testis, placenta, skeletal muscle, spleen and leukocytes, and at a lower level in heart, lung, liver, kidney, pancreas, thymus, prostate, colon, small intestine, bone marrow, mammary gland and uterus. Not expressed in brain. 9 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor
Chromosomal Location of Human Ortholog: 12 C3|12 33.52 cM
Cellular Component:  cilium; cytoplasm; mitochondrion; neuron projection; neuronal cell body; nucleus; perikaryon; perinuclear region of cytoplasm; plasma membrane; protein-DNA complex
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; drug binding; enzyme binding; estradiol binding; estrogen receptor activity; estrogen response element binding; hormone binding; identical protein binding; lipid binding; metal ion binding; nuclear receptor activity; peroxisome proliferator activated receptor binding; promoter-specific chromatin binding; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding; steroid binding; steroid hormone binding; steroid hormone receptor activity; zinc ion binding
Biological Process:  behavioral fear response; brain development; cellular response to estradiol stimulus; epithelial cell maturation involved in prostate gland development; estrous cycle; hormone-mediated apoptotic signaling pathway; intracellular estrogen receptor signaling pathway; intracellular steroid hormone receptor signaling pathway; learning or memory; negative regulation of androgen receptor signaling pathway; negative regulation of behavior; negative regulation of cell death; negative regulation of cell proliferation; negative regulation of epithelial cell proliferation; negative regulation of feeding behavior; negative regulation of neuron death; negative regulation of reactive oxygen species metabolic process; negative regulation of smooth muscle cell proliferation; negative regulation of transcription by RNA polymerase II; neuron migration; ovarian follicle development; positive regulation of apoptotic process; positive regulation of blood vessel diameter; positive regulation of DNA-binding transcription factor activity; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of ERK1 and ERK2 cascade; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; prostate gland epithelium morphogenesis; regulation of cell proliferation; regulation of neuron apoptotic process; regulation of transcription, DNA-templated; response to testosterone; Sertoli cell proliferation; uterus development; vagina development
Reference #:  O08537 (UniProtKB)
Alt. Names/Synonyms: ER beta; ER-beta; ER[b]; ERbeta; Esr2; Estrb; estrogen receptor 2 (beta); Estrogen receptor beta; Nr3a2; Nuclear receptor subfamily 3 group A member 2; oestrogen receptor beta; OTTMUSP00000023299; OTTMUSP00000023324
Gene Symbols: Esr2
Molecular weight: 59,070 Da
Basal Isoelectric point: 8.84  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA