IGHA1 Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen. Ig alpha is the major immunoglobulin class in body secretions. Note: This description may include information from UniProtKB.
Protein type: Immunoglobulin superfamily
Chromosomal Location of Human Ortholog: 14q32.33
Cellular Component:  extracellular region; extracellular space; monomeric IgA immunoglobulin complex; secretory dimeric IgA immunoglobulin complex; secretory IgA immunoglobulin complex
Molecular Function:  antigen binding
Biological Process:  antibacterial humoral response; glomerular filtration; immune response; leukocyte migration; positive regulation of respiratory burst; protein-chromophore linkage; receptor-mediated endocytosis
Reference #:  P01876 (UniProtKB)
Alt. Names/Synonyms: FLJ14473; FLJ35065; FLJ35500; FLJ36402; FLJ39698; FLJ40001; FLJ41548; FLJ41552; FLJ41789; FLJ43248; FLJ43594; FLJ44293; Ig alpha-1 chain C region; Ig alpha-1 chain C region BUR; Ig alpha-1 chain C region TRO; IgA1; IGHA1; immunoglobulin alpha 1; immunoglobulin heavy chain constant region alpha 1; Immunoglobulin heavy constant alpha 1; MGC102857
Gene Symbols: IGHA1
Molecular weight: 37,655 Da
Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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