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MSRA
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. Belongs to the MsrA Met sulfoxide reductase family. Ubiquitous. Highest expression in adult kidney and cerebellum, followed by liver, heart ventricles, bone marrow and hippocampus. 5 human isoforms generated by alternative promoter usage, alternative splicing or alternative initiation have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 1.8.4.11; Mitochondrial; Oxidoreductase |
| Chromosomal Location of human Ortholog: 8p23.1 |
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Cellular Component:
actin cytoskeleton; cytoplasm; cytosol; intracellular membrane-bounded organelle; midbody; mitochondrion; nucleoplasm; plasma membrane
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Molecular Function:
L-methionine-(S)-S-oxide reductase activity; peptide-methionine (S)-S-oxide reductase activity; protein binding
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Biological Process:
cellular response to oxidative stress; methionine metabolic process; protein modification process; protein repair; response to oxidative stress
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Reference #:
Q9UJ68
(UniProtKB)
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Alt. Names/Synonyms: cytosolic methionine-S-sulfoxide reductase; methionine sulfoxide reductase A; Mitochondrial peptide methionine sulfoxide reductase; MSRA; peptide met (O) reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase; Peptide-methionine (S)-S-oxide reductase; PMSR; Protein-methionine-S-oxide reductase
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Gene Symbols: MSRA
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Molecular weight:
26,132 Da
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Basal Isoelectric point:
8.22
Predict pI for various phosphorylation states
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