Huntingtin Huntingtin: May play a role in microtubule-mediated transport or vesicle function. Huntingtin, myristoylated N-terminal fragment: Promotes the formation of autophagic vesicles. Belongs to the huntingtin family. Expressed in the brain cortex (at protein level). Widely expressed with the highest level of expression in the brain (nerve fibers, varicosities, and nerve endings). In the brain, the regions where it can be mainly found are the cerebellar cortex, the neocortex, the striatum, and the hippocampal formation. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of mouse Ortholog: 5 B2|5 17.92 cM
Cellular Component:  autophagosome; axon; centriole; clathrin-coated vesicle; cytoplasm; cytoplasmic vesicle; cytoplasmic vesicle membrane; cytosol; dendrite; endoplasmic reticulum; glutamatergic synapse; Golgi apparatus; inclusion body; late endosome; neuronal cell body; neuronal ribonucleoprotein granule; nucleoplasm; nucleus; perinuclear region of cytoplasm; postsynaptic cytosol; postsynaptic density; presynaptic cytosol; protein-containing complex; synaptic membrane
Molecular Function:  beta-tubulin binding; diazepam binding; dynactin binding; dynein intermediate chain binding; heat shock protein binding; identical protein binding; ion channel binding; kinase binding; p53 binding; profilin binding; protein binding; signaling receptor binding; transcription factor binding
Biological Process:  anatomical structure morphogenesis; anterior/posterior pattern specification; apoptotic process; associative learning; axo-dendritic transport; brain development; cell aging; central nervous system development; citrulline metabolic process; determination of adult lifespan; dopamine receptor signaling pathway; endoplasmic reticulum organization; endosomal transport; ER to Golgi vesicle-mediated transport; establishment of mitotic spindle orientation; gastrulation; Golgi organization; grooming behavior; hormone metabolic process; insulin secretion; iron ion homeostasis; L-glutamate import; lactate biosynthetic process from pyruvate; learning; learning or memory; locomotory behavior; mitochondrial transport; mitochondrion organization; mRNA transport; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of neuron apoptotic process; negative regulation of neuron death; neural plate formation; neurogenesis; neuron apoptotic process; neuron development; olfactory lobe development; paraxial mesoderm formation; peptide hormone secretion; positive regulation of aggrephagy; positive regulation of apoptotic process; positive regulation of autophagy of mitochondrion; positive regulation of cilium assembly; positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; positive regulation of lipophagy; positive regulation of motile cilium assembly; positive regulation of non-motile cilium assembly; postsynapse to nucleus signaling pathway; protein destabilization; protein localization to centrosome; protein localization to nucleus; quinolinate biosynthetic process; regulation of CAMKK-AMPK signaling cascade; regulation of cAMP-dependent protein kinase activity; regulation of gene expression; regulation of intracellular mRNA localization; regulation of mitochondrial membrane permeability; regulation of mitochondrial membrane potential; regulation of neuron apoptotic process; regulation of phosphoprotein phosphatase activity; regulation of protein localization to nucleus; regulation of synaptic plasticity; response to calcium ion; retrograde vesicle-mediated transport, Golgi to ER; social behavior; spermatogenesis; striatum development; urea cycle; vesicle transport along microtubule; visual learning; vocal learning
Reference #:  P42859 (UniProtKB)
Alt. Names/Synonyms: AI256365; C430023I11Rik; Hd; HD protein homolog; Hdh; Htt; hunti; Huntingtin; Huntingtin, myristoylated N-terminal fragment; Huntington disease gene homolog; Huntington disease protein homolog; IT1; IT15; OTTMUSP00000026909
Gene Symbols: Htt
Molecular weight: 344,690 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
CST Pathways:  PI3K/Akt Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene