MAOB
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine. Belongs to the flavin monoamine oxidase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - glycine, serine and threonine; Amino Acid Metabolism - histidine; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - tyrosine; EC 1.4.3.4; Membrane protein, integral; Mitochondrial; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450 |
Chromosomal Location of mouse Ortholog: X A1.2|X 11.88 cM |
Cellular Component:
membrane; mitochondrial outer membrane; mitochondrion
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Molecular Function:
aliphatic amine oxidase activity; aminoacetone:oxygen oxidoreductase(deaminating) activity; flavin adenine dinucleotide binding; identical protein binding; monoamine oxidase activity; oxidoreductase activity; phenethylamine:oxygen oxidoreductase (deaminating) activity; primary amine oxidase activity; tryptamine:oxygen oxidoreductase (deaminating) activity
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Biological Process:
negative regulation of serotonin secretion; neurotransmitter catabolic process; positive regulation of dopamine metabolic process
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Reference #:
Q8BW75
(UniProtKB)
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Alt. Names/Synonyms: 6330414K01Rik; Amine oxidase [flavin-containing] B; AOFB; MAO; MAO-B; Maob; monoamine oxidase B; Monoamine oxidase type B; OTTMUSP00000018395
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Gene Symbols: Maob
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Molecular weight:
58,558 Da
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Basal Isoelectric point:
8.52
Predict pI for various phosphorylation states
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