separase a caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. Regulated by at least two independent mechanisms. First, it is inactivated via its interaction with securin/PTTG1, which probably covers its active site. Second, phosphorylation inactivates it. It is completely phosphorylated during mitosis and dephosphorylated during anaphase. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC; Protease
Chromosomal Location of Human Ortholog: 15|15 F3
Cellular Component:  centrosome; cytoplasm; mitotic spindle; nucleus
Molecular Function:  cysteine-type endopeptidase activity; cysteine-type peptidase activity; hydrolase activity; peptidase activity
Biological Process:  chromosome segregation; homologous chromosome segregation; meiosis I; meiotic chromosome separation; meiotic spindle organization; mitotic cell cycle; mitotic sister chromatid segregation; proteolysis
Reference #:  P60330 (UniProtKB)
Alt. Names/Synonyms: AL024103; AU045071; caspase-like protein ESPL1; Cerp; Cut1/ESP1 related protein; ESP1; Espl1; extra spindle poles-like 1 (S. cerevisiae); extra spindle poles-like 1 protein; PRCE; Protein related to CUT1 and ESP1; separase; Separin; SSE
Gene Symbols: Espl1
Molecular weight: 233,035 Da
Basal Isoelectric point: 6.49  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein