separase
Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 3.4.22.49; Protease |
Chromosomal Location of mouse Ortholog: 15|15 F3 |
Cellular Component:
centrosome; cytoplasm; mitotic spindle; nucleus
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Molecular Function:
cysteine-type endopeptidase activity; cysteine-type peptidase activity; hydrolase activity; peptidase activity
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Biological Process:
chromosome segregation; homologous chromosome segregation; meiosis I; meiotic chromosome separation; meiotic spindle organization; mitotic cell cycle; mitotic sister chromatid segregation; proteolysis
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Reference #:
P60330
(UniProtKB)
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Alt. Names/Synonyms: AL024103; AU045071; caspase-like protein ESPL1; Cerp; Cut1/ESP1 related protein; ESP1; Espl1; extra spindle pole bodies 1, separase; extra spindle poles-like 1 (S. cerevisiae); extra spindle poles-like 1 protein; Kiaa0165; PRCE; Protein related to CUT1 and ESP1; separase; Separin; SSE
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Gene Symbols: Espl1
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Molecular weight:
233,035 Da
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Basal Isoelectric point:
6.49
Predict pI for various phosphorylation states
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