separase Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.22.49; Protease
Chromosomal Location of mouse Ortholog: 15|15 F3
Cellular Component:  centrosome; cytoplasm; mitotic spindle; nucleus
Molecular Function:  cysteine-type endopeptidase activity; cysteine-type peptidase activity; hydrolase activity; peptidase activity
Biological Process:  chromosome segregation; homologous chromosome segregation; meiosis I; meiotic chromosome separation; meiotic spindle organization; mitotic cell cycle; mitotic sister chromatid segregation; proteolysis
Reference #:  P60330 (UniProtKB)
Alt. Names/Synonyms: AL024103; AU045071; caspase-like protein ESPL1; Cerp; Cut1/ESP1 related protein; ESP1; Espl1; extra spindle pole bodies 1, separase; extra spindle poles-like 1 (S. cerevisiae); extra spindle poles-like 1 protein; Kiaa0165; PRCE; Protein related to CUT1 and ESP1; separase; Separin; SSE
Gene Symbols: Espl1
Molecular weight: 233,035 Da
Basal Isoelectric point: 6.49  Predict pI for various phosphorylation states
Select Structure to View Below

separase

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein