EphA8 Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Eph family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of mouse Ortholog: 4|4 D3
Cellular Component:  cell projection; endosome; integral component of membrane; integral component of plasma membrane; membrane; neuron projection; plasma membrane; receptor complex
Molecular Function:  ATP binding; ephrin receptor activity; GPI-linked ephrin receptor activity; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity; transmembrane-ephrin receptor activity
Biological Process:  axon guidance; cell adhesion; cellular response to follicle-stimulating hormone stimulus; ephrin receptor signaling pathway; multicellular organism development; nervous system development; neuron projection development; neuron remodeling; phosphorylation; positive regulation of MAPK cascade; positive regulation of phosphatidylinositol 3-kinase activity; protein autophosphorylation; protein phosphorylation; regulation of cell adhesion; regulation of cell adhesion mediated by integrin; substrate-dependent cell migration; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  O09127 (UniProtKB)
Alt. Names/Synonyms: AW047546; Eek; Eph; Eph receptor A8; EPH- and ELK-related kinase; Epha8; Ephrin type-A receptor 8; Ephrin type-A receptor 8 precursor (Tyrosine-protein kinase receptor EEK) (EPH-and ELK-related kinase); Hek3; KIAA1459; mKIAA1459; OTTMUSP00000010386; Tyrosine-protein kinase receptor EEK
Gene Symbols: Epha8
Molecular weight: 110,705 Da
Basal Isoelectric point: 8.28  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene