ABAT
Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. Liver Note: This description may include information from UniProtKB.
|
Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - propanoate; EC 2.6.1.19; EC 2.6.1.22; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Transferase |
Chromosomal Location of mouse Ortholog: 16|16 A1 |
Cellular Component:
4-aminobutyrate transaminase complex; mitochondrial matrix; mitochondrion
|
Molecular Function:
(S)-3-amino-2-methylpropionate transaminase activity; 4-aminobutyrate transaminase activity; 4-aminobutyrate:2-oxoglutarate transaminase activity; catalytic activity; identical protein binding; iron-sulfur cluster binding; metal ion binding; pyridoxal phosphate binding; transaminase activity; transferase activity
|
Biological Process:
behavioral response to cocaine; copulation; exploration behavior; gamma-aminobutyric acid biosynthetic process; gamma-aminobutyric acid catabolic process; gamma-aminobutyric acid metabolic process; locomotory behavior; negative regulation of blood pressure; negative regulation of dopamine secretion; negative regulation of gamma-aminobutyric acid secretion; neurotransmitter catabolic process; positive regulation of aspartate secretion; positive regulation of dopamine metabolic process; positive regulation of heat generation; positive regulation of inhibitory postsynaptic potential; positive regulation of insulin secretion; positive regulation of prolactin secretion; positive regulation of uterine smooth muscle contraction; response to cocaine; response to ethanol; response to hypoxia; response to iron ion; response to nicotine; response to xenobiotic stimulus
|
Reference #:
P61922
(UniProtKB)
|
Alt. Names/Synonyms: (S)-3-amino-2-methylpropionate transaminase; 4-aminobutyrate aminotransferase; 4-aminobutyrate aminotransferase, mitochondrial; 4-aminobutyrate transaminase; 9630038C02Rik; Abat; AI255750; beta-alanine oxoglutarate aminotransferase; ENSMUSG00000051226; GABA; GABA aminotransferase; GABA transaminase; GABA transferase; GABA-AT; GABA-T; Gabaat; Gabat; GABT; Gamma-amino-N-butyrate transaminase; Gm9851; I54; L-AIBAT; Laibat; OTTMUSP00000031702; X61497
|
Gene Symbols: Abat
|
Molecular weight:
56,452 Da
|
Basal Isoelectric point:
8.35
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|