HSD17B8 NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heterotetramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis. Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD. Belongs to the short-chain dehydrogenases/reductases (SDR) family. Highly expressed in placenta, liver and pancreas, lower in the skeletal muscle and kidney. Widely expressed. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Lipid Metabolism - androgen and estrogen; Mitochondrial; Oxidoreductase
Chromosomal Location of human Ortholog: 6p21.32
Cellular Component:  mitochondrial envelope; mitochondrial matrix; oxidoreductase complex; plasma membrane
Molecular Function:  (3R)-hydroxyacyl-CoA dehydrogenase (NAD) activity; estradiol 17-beta-dehydrogenase [NAD(P)] activity; NADH binding; protein binding; testosterone dehydrogenase (NAD+) activity
Biological Process:  androgen metabolic process; estrogen biosynthetic process; fatty acid biosynthetic process; protein heterotetramerization
Reference #:  Q92506 (UniProtKB)
Alt. Names/Synonyms: (3R)-3-hydroxyacyl-CoA dehydrogenase; 17-beta-HSD 8; 17-beta-hydroxysteroid dehydrogenase 8; 3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit; 3-oxoacyl-[acyl-carrier-protein] reductase; beta-ketoacyl-[acyl-carrier-protein] reductase-like; D6S2245E; DHB8; dJ1033B10.9; Estradiol 17-beta-dehydrogenase 8; estrogen 17-oxidoreductase; FABG; FABGL; H2-KE6; HKE6; HSD17B8; hydroxysteroid (17-beta) dehydrogenase 8; hydroxysteroid 17-beta dehydrogenase 8; KAR alpha subunit; Ke-6; KE6; Protein Ke6; Really interesting new gene 2 protein; RING2; SDR30C1; Short chain dehydrogenase/reductase family 30C member 1; short chain dehydrogenase/reductase family 30C, member 1; Testosterone 17-beta-dehydrogenase 8
Gene Symbols: HSD17B8
Molecular weight: 26,974 Da
Basal Isoelectric point: 6.09  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein