|
SHC1
Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. Widely expressed. Expressed in neural stem cells but absent in mature neurons. 6 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 3 F1|3 39.11 cM |
|
Cellular Component:
anchoring junction; cytoplasm; cytosol; endosome membrane; mitochondrion; plasma membrane; Shc-EGFR complex
|
|
Molecular Function:
ephrin receptor binding; epidermal growth factor binding; epidermal growth factor receptor binding; identical protein binding; insulin receptor binding; insulin-like growth factor receptor binding; neurotrophin TRKA receptor binding; phosphoprotein binding; phosphotyrosine residue binding; protein binding; protein phosphatase 2A binding; protein-containing complex binding; receptor tyrosine kinase binding; transmembrane receptor protein tyrosine kinase adaptor activity
|
|
Biological Process:
actin cytoskeleton organization; angiogenesis; cell-cell adhesion; cellular response to growth factor stimulus; defense response to bacterium; epidermal growth factor receptor signaling pathway; heart development; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; intracellular signal transduction; negative regulation of angiogenesis; negative regulation of apoptotic process; negative regulation of DNA-templated transcription; neuron differentiation; neuron projection development; positive regulation of cell population proliferation; positive regulation of cell proliferation in bone marrow; positive regulation of DNA-templated transcription; positive regulation of ERK1 and ERK2 cascade; positive regulation of MAPK cascade; positive regulation of smooth muscle cell proliferation; positive regulation of vasoconstriction; regulation of cell population proliferation; regulation of smooth muscle contraction; regulation of superoxide metabolic process; response to endothelin
|
|
Reference #:
P98083
(UniProtKB)
|
|
Alt. Names/Synonyms: OTTMUSP00000024847; p66; p66s; p66shc; SH2 domain protein C1; Shc; SHC-transforming protein 1; SHC-transforming protein A; Shc1; ShcA; src homology 2 domain-containing transforming protein C1; Src homology 2 domain-containing-transforming protein C1
|
|
Gene Symbols: Shc1
|
|
Molecular weight:
62,608 Da
|
|
Basal Isoelectric point:
6.09
Predict pI for various phosphorylation states
|
|
CST Pathways:
B Cell Receptor Signaling
|
ErbB/HER Signaling
|
Growth And Differentiation Control by MAPKs
|
IL6 Signaling
|
Insulin Receptor Signaling
|
SAPK/JNK Signaling Cascades
|
TGF-ß Signaling
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
