OTC Belongs to the ATCase/OTCase family. Mainly expressed in liver and intestinal mucosa. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - arginine and proline; EC; Mitochondrial; Transferase
Chromosomal Location of Human Ortholog: Xp11.4
Cellular Component:  mitochondrial inner membrane; mitochondrial matrix; mitochondrion
Molecular Function:  amino acid binding; ornithine carbamoyltransferase activity; phosphate ion binding; phospholipid binding
Biological Process:  ammonia homeostasis; anion homeostasis; citrulline biosynthetic process; liver development; midgut development; ornithine catabolic process; protein homotrimerization; response to biotin; response to insulin; response to zinc ion; urea cycle
Disease: Ornithine Transcarbamylase Deficiency, Hyperammonemia Due To
Reference #:  P00480 (UniProtKB)
Alt. Names/Synonyms: MGC129967; MGC129968; MGC138856; OCTD; ornithine carbamoyltransferase; Ornithine carbamoyltransferase, mitochondrial; Ornithine transcarbamylase; OTC; OTCase
Gene Symbols: OTC
Molecular weight: 39,935 Da
Basal Isoelectric point: 8.75  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene