SHP-1 Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis. Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily. Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)
Chromosomal Location of mouse Ortholog: 6 F2|6 59.17 cM
Cellular Component:  alpha-beta T cell receptor complex; apical dendrite; cell-cell junction; cytoplasm; cytosol; nucleolus; nucleoplasm; nucleus; protein-containing complex
Molecular Function:  cell adhesion molecule binding; cytokine receptor binding; hydrolase activity; natural killer cell lectin-like receptor binding; non-membrane spanning protein tyrosine phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; phosphorylation-dependent protein binding; phosphotyrosine residue binding; protein binding; protein kinase binding; protein tyrosine phosphatase activity; SH2 domain binding; SH3 domain binding; transmembrane receptor protein tyrosine phosphatase activity
Biological Process:  B cell receptor signaling pathway; cell differentiation; cytokine-mediated signaling pathway; dephosphorylation; epididymis development; hematopoietic progenitor cell differentiation; intracellular signal transduction; MAPK cascade; megakaryocyte development; mitotic cell cycle; natural killer cell mediated cytotoxicity; negative regulation of humoral immune response mediated by circulating immunoglobulin; negative regulation of inflammatory response to wounding; negative regulation of interleukin-6 production; negative regulation of MAP kinase activity; negative regulation of MAPK cascade; negative regulation of mast cell activation involved in immune response; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of T cell proliferation; negative regulation of T cell receptor signaling pathway; negative regulation of tumor necrosis factor production; peptidyl-tyrosine dephosphorylation; peptidyl-tyrosine phosphorylation; platelet aggregation; platelet formation; positive regulation of cell adhesion mediated by integrin; positive regulation of cell population proliferation; positive regulation of phosphatidylinositol 3-kinase signaling; protein dephosphorylation; regulation of B cell differentiation; regulation of ERK1 and ERK2 cascade; regulation of G1/S transition of mitotic cell cycle; regulation of release of sequestered calcium ion into cytosol; T cell proliferation; T cell receptor signaling pathway
Reference #:  P29351 (UniProtKB)
Alt. Names/Synonyms: 70Z-SHP; Hcp; Hcph; Hematopoietic cell protein-tyrosine phosphatase; hemopoietic cell phosphatase; me; motheaten; protein tyrosine phosphatase, non-receptor type 6; Protein-tyrosine phosphatase 1C; PTN6; Ptp; PTP-1C; Ptp1C; Ptpn6; PTPTY-42; SH-PTP1; SH2 phosphatase 1; SHP; SHP-1; Tyrosine-protein phosphatase non-receptor type 6
Gene Symbols: Ptpn6
Molecular weight: 67,559 Da
Basal Isoelectric point: 7.66  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  IL6 Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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SHP-1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene