EphA8 iso2 Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)
Chromosomal Location of human Ortholog: 1p36.12
Cellular Component:  early endosome membrane; integral component of plasma membrane; neuron projection; plasma membrane
Molecular Function:  ATP binding; GPI-linked ephrin receptor activity
Biological Process:  axon guidance; cell adhesion; cellular response to follicle-stimulating hormone stimulus; ephrin receptor signaling pathway; neuron projection development; neuron remodeling; peptidyl-tyrosine phosphorylation; positive regulation of MAPK cascade; positive regulation of phosphatidylinositol 3-kinase activity; protein autophosphorylation; regulation of cell adhesion; regulation of cell adhesion mediated by integrin; substrate-dependent cell migration
Reference #:  P29322-2 (UniProtKB)
Alt. Names/Synonyms: EEK; EK3; EPH receptor A8; EPH- and ELK-related kinase; EPH- and ELK-related tyrosine kinase; EPH-like kinase 3; EPHA8; EphA8 iso2; Ephrin type-A receptor 8; HEK3; hydroxyaryl-protein kinase; KIAA1459; protein-tyrosine kinase; tyrosine-protein kinase receptor EEK; tyrosylprotein kinase
Gene Symbols: EPHA8
Molecular weight: 53,900 Da
Basal Isoelectric point: 6.38  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Select Structure to View Below

EphA8 iso2

Protein Structure Not Found.


Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene