Siva Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. Ubiquitous. Mostly expressed in thymus, testis, ovary, prostate, small intestine and spleen and less in colon. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 12|12 F1
Cellular Component:  cytoplasm; mitochondrion; nucleoplasm; nucleus
Molecular Function:  CD27 receptor binding; metal ion binding; tumor necrosis factor receptor binding; virus receptor activity; zinc ion binding
Biological Process:  activation-induced cell death of T cells; apoptotic process; extrinsic apoptotic signaling pathway; negative regulation of NF-kappaB transcription factor activity; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
Reference #:  O54926 (UniProtKB)
Alt. Names/Synonyms: Apoptosis regulatory protein Siva; Cd27 binding protein; CD27-binding protein; CD27b; CD27BP; Siva; Siva1; SIVA1, apoptosis-inducing factor
Gene Symbols: Siva1
Molecular weight: 18,770 Da
Basal Isoelectric point: 7.43  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene