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Siva
Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. Ubiquitous. Mostly expressed in thymus, testis, ovary, prostate, small intestine and spleen and less in colon. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis |
| Chromosomal Location of mouse Ortholog: 12|12 F1 |
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Cellular Component:
cytoplasm; mitochondrion; nucleoplasm; nucleus
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Molecular Function:
CD27 receptor binding; metal ion binding; tumor necrosis factor receptor binding; virus receptor activity; zinc ion binding
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Biological Process:
activation-induced cell death of T cells; apoptotic process; extrinsic apoptotic signaling pathway; negative regulation of NF-kappaB transcription factor activity; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
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Reference #:
O54926
(UniProtKB)
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Alt. Names/Synonyms: Apoptosis regulatory protein Siva; Cd27 binding protein; CD27-binding protein; CD27b; CD27BP; Siva; Siva1; SIVA1, apoptosis-inducing factor
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Gene Symbols: Siva1
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Molecular weight:
18,770 Da
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Basal Isoelectric point:
7.43
Predict pI for various phosphorylation states
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