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CPPED1
Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes. Belongs to the metallophosphoesterase superfamily. CPPED1 family. Expressed in subcutaneous adipose tissue. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.3.16; Hydrolase |
| Chromosomal Location of human Ortholog: 16p13.12 |
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Cellular Component:
azurophil granule lumen; cytosol; extracellular region; plasma membrane
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Molecular Function:
metal ion binding; myosin phosphatase activity
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Reference #:
Q9BRF8
(UniProtKB)
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Alt. Names/Synonyms: calcineurin like phosphoesterase domain containing 1; calcineurin-like phosphoesterase domain containing 1; Calcineurin-like phosphoesterase domain-containing protein 1; complete S transactivated protein 1; Complete S-transactivated protein 1; CPPED; CPPED1; CSTP1; FLJ11151; Serine/threonine-protein phosphatase CPPED1
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Gene Symbols: CPPED1
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Molecular weight:
35,548 Da
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Basal Isoelectric point:
5.79
Predict pI for various phosphorylation states
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