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EAR-2
Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). Belongs to the nuclear hormone receptor family. NR2 subfamily. Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Nuclear receptor |
| Chromosomal Location of rat Ortholog: 16p14 |
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Cellular Component:
nucleus
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Molecular Function:
DNA-binding transcription factor activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; nuclear receptor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; zinc ion binding
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Biological Process:
anatomical structure development; cell differentiation; detection of temperature stimulus involved in sensory perception of pain; DNA-templated transcription; entrainment of circadian clock by photoperiod; intracellular receptor signaling pathway; negative regulation of transcription by RNA polymerase II; neuron development
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Reference #:
O09017
(UniProtKB)
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Alt. Names/Synonyms: COUPg; EAR-2; Ear2; Erbal2; Nr2f6; Nuclear receptor subfamily 2 group F member 6; nuclear receptor subfamily 2, group F, member 6; orphan nuclear receptor EAR-2; ovalbumin upstream promoter gamma nuclear receptor rCOUPg; V-erbA-related protein 2; V-erbA-related protein EAR-2
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Gene Symbols: Nr2f6
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Molecular weight:
41,730 Da
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Basal Isoelectric point:
7.05
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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