SLP76 Involved in T-cell antigen receptor mediated signaling. Highly expressed in spleen, thymus and peripheral blood leukocytes. Highly expressed also in T-cell and monocytic cell lines, expressed at lower level in B-cell lines. Not detected in fibroblast or neuroblastoma cell lines. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of mouse Ortholog: 11|11 A4
Cellular Component:  cell-cell junction; cytoplasm; cytosol; plasma membrane raft; TCR signalosome
Molecular Function:  protein binding
Biological Process:  cytokine production; intracellular signal transduction; mast cell activation; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  Q60787 (UniProtKB)
Alt. Names/Synonyms: AI323664; BB161688; Lcp2; Lymphocyte cytosolic protein 2; m1Kho; m1Khoe; RP23-216O18.1; SH2 domain-containing leukocyte protein of 76 kDa; SLP; SLP-76; SLP-76 tyrosine phosphoprotein; SLP76; twm
Gene Symbols: Lcp2
Molecular weight: 60,238 Da
Basal Isoelectric point: 5.85  Predict pI for various phosphorylation states
CST Pathways:  T Cell Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein