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SLP76
Involved in T-cell antigen receptor mediated signaling. Highly expressed in spleen, thymus and peripheral blood leukocytes. Highly expressed also in T-cell and monocytic cell lines, expressed at lower level in B-cell lines. Not detected in fibroblast or neuroblastoma cell lines. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of mouse Ortholog: 11|11 A4 |
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Cellular Component:
cell-cell junction; cytoplasm; cytosol; plasma membrane raft; TCR signalosome
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Molecular Function:
protein binding
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Biological Process:
cytokine production; intracellular signal transduction; mast cell activation; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway
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Reference #:
Q60787
(UniProtKB)
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Alt. Names/Synonyms: AI323664; BB161688; Lcp2; Lymphocyte cytosolic protein 2; m1Kho; m1Khoe; RP23-216O18.1; SH2 domain-containing leukocyte protein of 76 kDa; SLP; SLP-76; SLP-76 tyrosine phosphoprotein; SLP76; twm
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Gene Symbols: Lcp2
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Molecular weight:
60,238 Da
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Basal Isoelectric point:
5.85
Predict pI for various phosphorylation states
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CST Pathways:
T Cell Receptor Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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