NR2C1 Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation. Belongs to the nuclear hormone receptor family. NR2 subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor
Chromosomal Location of Human Ortholog: 7q13
Cellular Component:  nucleus; PML body
Molecular Function:  DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; histone deacetylase binding; protein homodimerization activity; RNA polymerase II proximal promoter sequence-specific DNA binding; steroid hormone receptor activity; zinc ion binding
Biological Process:  negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; positive regulation of retinoic acid receptor signaling pathway; steroid hormone mediated signaling pathway
Reference #:  Q8VIJ4 (UniProtKB)
Alt. Names/Synonyms: Nr2c1; Nuclear receptor subfamily 2 group C member 1; nuclear receptor subfamily 2, group H, member 1; orphan nuclear receptor TR2; orphan receptor, TR2-11; pregnancy specific beta-1-glycoprotein 4; Psg4; testicular receptor 2; Tr2; TR2-11
Gene Symbols: Nr2c1
Molecular weight: 65,528 Da
Basal Isoelectric point: 6.14  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein