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RXRA
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes. Belongs to the nuclear hormone receptor family. NR2 subfamily. Highly expressed in liver, also found in lung, kidney and heart. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor |
| Chromosomal Location of rat Ortholog: 3p12 |
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Cellular Component:
axon; chromatin; mitochondrion; nucleus; receptor complex; RNA polymerase II transcription regulator complex; transcription regulator complex
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Molecular Function:
chromatin DNA binding; DNA binding; DNA binding domain binding; DNA-binding transcription factor activity; double-stranded DNA binding; enzyme binding; identical protein binding; ion binding; LBD domain binding; nuclear receptor activity; nuclear receptor binding; nuclear retinoic acid receptor binding; nuclear steroid receptor activity; nuclear thyroid hormone receptor binding; nuclear vitamin D receptor binding; peptide binding; protein binding; protein domain specific binding; protein-containing complex binding; retinoic acid binding; retinoic acid-responsive element binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding; transcription coactivator binding; transcription coregulator binding; vitamin D response element binding; zinc ion binding
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Biological Process:
anatomical structure development; axon regeneration; camera-type eye development; cardiac muscle cell proliferation; cell differentiation; cellular response to insulin stimulus; DNA-templated transcription; embryo implantation; female pregnancy; gene expression; heart development; hormone-mediated signaling pathway; in utero embryonic development; liver development; maternal placenta development; midgut development; mRNA transcription by RNA polymerase II; negative regulation of cell population proliferation; negative regulation of transcription by RNA polymerase II; peroxisome proliferator activated receptor signaling pathway; placenta development; positive regulation of apoptotic process; positive regulation of DNA-templated transcription; positive regulation of thyroid hormone mediated signaling pathway; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; positive regulation of translational initiation by iron; positive regulation of vitamin D receptor signaling pathway; regulation of branching involved in prostate gland morphogenesis; regulation of DNA-templated transcription; regulation of myelination; regulation of transcription by RNA polymerase II; response to ethanol; response to glucocorticoid; response to nutrient; response to organic cyclic compound; response to retinoic acid; response to selenium ion; response to vitamin A; response to vitamin D; retinoic acid receptor signaling pathway; secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development; steroid hormone mediated signaling pathway; ventricular cardiac muscle cell differentiation; ventricular cardiac muscle tissue morphogenesis
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Reference #:
Q05343
(UniProtKB)
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Alt. Names/Synonyms: Nr2b1; nuclear receptor subfamily 2 group B member 1; Retinoic acid receptor RXR-alpha; Retinoid X receptor alpha; Rxra
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Gene Symbols: Rxra
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Molecular weight:
51,266 Da
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Basal Isoelectric point:
7.58
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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