SHC1 Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. Widely expressed. Expressed in neural stem cells but absent in mature neurons. 6 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2q34
Cellular Component:  cytoplasm; cytosol; endosome membrane; nucleus; plasma membrane; Shc-EGFR complex
Molecular Function:  ephrin receptor binding; epidermal growth factor binding; epidermal growth factor receptor binding; identical protein binding; insulin receptor binding; insulin-like growth factor receptor binding; neurotrophin TRKA receptor binding; phosphoprotein binding; phosphotyrosine residue binding; protein binding; protein phosphatase 2A binding; protein-containing complex binding; receptor tyrosine kinase binding
Biological Process:  actin cytoskeleton organization; actin cytoskeleton reorganization; activation of MAPK activity; aging; angiogenesis; animal organ regeneration; cell-cell adhesion; cellular response to growth factor stimulus; cellular response to insulin stimulus; defense response to bacterium; epidermal growth factor receptor signaling pathway; heart development; insulin receptor signaling pathway; intracellular signal transduction; MAPK cascade; negative regulation of angiogenesis; negative regulation of apoptotic process; negative regulation of transcription, DNA-templated; neuron differentiation; neuron projection development; positive regulation of cell proliferation; positive regulation of cell proliferation in bone marrow; positive regulation of ERK1 and ERK2 cascade; positive regulation of MAPK cascade; positive regulation of smooth muscle cell proliferation; positive regulation of transcription, DNA-templated; positive regulation of vasoconstriction; regulation of cell proliferation; regulation of growth; regulation of smooth muscle contraction; regulation of superoxide metabolic process; response to endothelin; response to glucocorticoid; response to hydrogen peroxide; response to hypoxia; response to insulin; response to nicotine; response to organic cyclic compound; response to toxic substance
Reference #:  G3V8S2 (UniProtKB)
Alt. Names/Synonyms: P66shc; SH2 domain protein C1; SHC (Src homology 2 domain containing) transforming protein 1; SHC (Src homology 2 domain-containing) transforming protein 1; SHC-transforming protein 1; Shc1; src homology 2 domain-containing transforming protein C1; Src homology 2 domain-containing-transforming protein C1
Gene Symbols: Shc1
Molecular weight: 62,686 Da
Basal Isoelectric point: 6.09  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Insulin Receptor Signaling  |  SAPK/JNK Signaling Cascades  |  TGF-ß Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein