SMAD1
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Belongs to the dwarfin/SMAD family. Ubiquitous. Highest expression seen in the heart and skeletal muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: DNA-binding; Transcription factor |
Chromosomal Location of mouse Ortholog: 8|8 C1 |
Cellular Component:
cytoplasm; heteromeric SMAD protein complex; homomeric SMAD protein complex; nuclear inner membrane; nucleus; protein-containing complex; transcription regulator complex
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Molecular Function:
co-SMAD binding; DEAD/H-box RNA helicase binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; I-SMAD binding; identical protein binding; metal ion binding; primary miRNA binding; protein binding; protein kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding
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Biological Process:
anatomical structure morphogenesis; BMP signaling pathway; bone development; cardiac muscle cell proliferation; cardiac muscle hypertrophy in response to stress; cartilage development; cell differentiation; cell population proliferation; cellular response to BMP stimulus; cellular response to organic cyclic compound; DNA-templated transcription; gamete generation; hindbrain development; homeostatic process; inflammatory response; MAPK cascade; mesodermal cell fate commitment; midbrain development; negative regulation of cell population proliferation; negative regulation of muscle cell differentiation; ossification; osteoblast differentiation; osteoblast fate commitment; positive regulation of cartilage development; positive regulation of cell differentiation; positive regulation of gene expression; positive regulation of miRNA transcription; positive regulation of osteoblast differentiation; positive regulation of sprouting angiogenesis; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; protein phosphorylation; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to xenobiotic stimulus; SMAD protein signal transduction; transcription by RNA polymerase II; transforming growth factor beta receptor signaling pathway; ureteric bud development
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Reference #:
P70340
(UniProtKB)
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Alt. Names/Synonyms: AI528653; Dwarfin-A; Dwf-A; Mad; MAD homolog 1; MAD homolog 1 (Drosophila); Mad-related protein 1; Mad1; Madh; Madh1; Madr1; Mlp1; mMad1; Mothers against decapentaplegic homolog 1; Mothers against DPP homolog 1; Mothers-against-DPP-related 1; MusMLP; OTTMUSP00000023243; SMAD 1; SMAD family member 1; Smad1
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Gene Symbols: Smad1
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Molecular weight:
52,157 Da
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Basal Isoelectric point:
6.9
Predict pI for various phosphorylation states
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CST Pathways:
ESC Pluripotency and Differentiation
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TGF-ß Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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