SMAD1 transcription factor phosphorylated and activated by bone morphogenetic protein type 1 receptor kinases. Participates in a wide range of critical processes including morphogenesis, cell-fate determination, proliferation, differentiation and apoptosis. Phosphorylated forms dimerize with collaborating Smad4 and are translocated into the nucleus, where the transcription of target genes is stimulated. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 8|8 C1
Cellular Component:  cytoplasm; nuclear inner membrane; nucleus; protein-containing complex; transcription factor complex
Molecular Function:  co-SMAD binding; DEAD/H-box RNA helicase binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; I-SMAD binding; identical protein binding; metal ion binding; primary miRNA binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding
Biological Process:  BMP signaling pathway; bone development; cardiac muscle cell proliferation; cartilage development; cellular response to BMP stimulus; cellular response to organic cyclic compound; gamete generation; hindbrain development; homeostatic process; inflammatory response; MAPK cascade; mesodermal cell fate commitment; midbrain development; negative regulation of cell proliferation; osteoblast fate commitment; positive regulation of cartilage development; positive regulation of cell differentiation; positive regulation of gene expression; positive regulation of osteoblast differentiation; positive regulation of pri-miRNA transcription by RNA polymerase II; positive regulation of sprouting angiogenesis; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; protein phosphorylation; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; response to drug; SMAD protein complex assembly; SMAD protein signal transduction; transforming growth factor beta receptor signaling pathway; ureteric bud development
Reference #:  P70340 (UniProtKB)
Alt. Names/Synonyms: AI528653; Dwarfin-A; Dwf-A; MAD homolog 1; MAD homolog 1 (Drosophila); Mad-related protein 1; Madh1; Madr1; Mlp1; mMad1; Mothers against decapentaplegic homolog 1; Mothers against DPP homolog 1; Mothers-against-DPP-related 1; MusMLP; OTTMUSP00000023243; SMAD 1; SMAD family member 1; Smad1
Gene Symbols: Smad1
Molecular weight: 52,157 Da
Basal Isoelectric point: 6.9  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene