eIF2B-epsilon Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Belongs to the eIF-2B gamma/epsilon subunits family. Note: This description may include information from UniProtKB.
Protein type: Translation; Translation initiation
Chromosomal Location of Human Ortholog: 11q23
Cellular Component:  cytoplasm; cytosol; eukaryotic translation initiation factor 2B complex; nucleus
Molecular Function:  guanyl-nucleotide exchange factor activity; protein binding; translation initiation factor activity; translation initiation factor binding
Biological Process:  aging; astrocyte development; astrocyte differentiation; hippocampus development; myelination; oligodendrocyte development; ovarian follicle development; positive regulation of apoptotic process; positive regulation of translation; positive regulation of translational initiation; response to endoplasmic reticulum stress; response to glucose; response to heat; response to lithium ion; response to peptide hormone; T cell receptor signaling pathway; translational initiation
Reference #:  Q64350 (UniProtKB)
Alt. Names/Synonyms: EI2BE; eIF-2B GDP-GTP exchange factor subunit epsilon; Eif2b5; Eif2be; eukaryotic translation initiation factor 2B, subunit 5 epsilon; initiation factor eIF-2Be; Translation initiation factor eIF-2B subunit epsilon
Gene Symbols: Eif2b5
Molecular weight: 80,206 Da
Basal Isoelectric point: 4.9  Predict pI for various phosphorylation states
CST Pathways:  Translation: eIF2  |  Translational Control
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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eIF2B-epsilon

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene