SOD1 Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; EC; Mitochondrial; Nuclear receptor co-regulator; Oxidoreductase
Chromosomal Location of human Ortholog: 21q22.11
Cellular Component:  axon cytoplasm; cytoplasm; cytoplasmic vesicle; cytosol; dendrite cytoplasm; dense core granule; extracellular region; extracellular space; lysosome; mitochondrial intermembrane space; mitochondrial matrix; mitochondrion; neuronal cell body; nucleoplasm; nucleus; peroxisome; plasma membrane; protein-containing complex
Molecular Function:  chaperone binding; copper ion binding; identical protein binding; ion binding; protein binding; protein phosphatase 2B binding; small GTPase binding; superoxide dismutase activity; zinc ion binding
Biological Process:  aging; anterograde axonal transport; apoptotic process; auditory receptor cell stereocilium organization; cellular iron ion homeostasis; cellular response to ATP; cellular response to cadmium ion; cellular response to potassium ion; ectopic germ cell programmed cell death; embryo implantation; glutathione metabolic process; heart contraction; hydrogen peroxide biosynthetic process; locomotory behavior; muscle cell cellular homeostasis; myeloid cell homeostasis; negative regulation of cholesterol biosynthetic process; negative regulation of developmental process; negative regulation of inflammatory response; negative regulation of neuron apoptotic process; negative regulation of reproductive process; neurofilament cytoskeleton organization; ovarian follicle development; peripheral nervous system myelin maintenance; placenta development; positive regulation of apoptotic process; positive regulation of catalytic activity; positive regulation of cytokine production; positive regulation of MAPK cascade; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; positive regulation of phagocytosis; positive regulation of superoxide anion generation; reactive oxygen species metabolic process; regulation of blood pressure; regulation of GTPase activity; regulation of mitochondrial membrane potential; regulation of multicellular organism growth; regulation of organ growth; regulation of protein kinase activity; regulation of T cell differentiation in thymus; relaxation of vascular associated smooth muscle; removal of superoxide radicals; response to amphetamine; response to antibiotic; response to antipsychotic drug; response to axon injury; response to carbon monoxide; response to copper ion; response to ethanol; response to heat; response to hydrogen peroxide; response to nutrient levels; response to organic substance; response to superoxide; response to xenobiotic stimulus; retina homeostasis; retrograde axonal transport; sensory perception of sound; spermatogenesis; superoxide anion generation; superoxide metabolic process; thymus development; transmission of nerve impulse
Disease: Amyotrophic Lateral Sclerosis 1; Spastic Tetraplegia And Axial Hypotonia, Progressive
Reference #:  P00441 (UniProtKB)
Alt. Names/Synonyms: ALS; ALS1; Cu/Zn superoxide dismutase; epididymis secretory protein Li 44; HEL-S-44; homodimer; hSod1; indophenoloxidase A; IPOA; SOD; SOD, soluble; SOD1; SODC; STAHP; superoxide dismutase; Superoxide dismutase 1; superoxide dismutase 1, soluble; Superoxide dismutase [Cu-Zn]; superoxide dismutase, cystolic
Gene Symbols: SOD1
Molecular weight: 15,936 Da
Basal Isoelectric point: 5.7  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  InnateDB