SOD1 Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. Note: This description may include information from UniProtKB.

Protein type: Apoptosis; EC 1.15.1.1; Mitochondrial; Nuclear receptor co-regulator; Oxidoreductase

Chromosomal Location of human Ortholog: 21q22.11

Cellular Component: axon cytoplasm; cytoplasm; cytoplasmic vesicle; cytosol; dendrite cytoplasm; dense core granule; extracellular region; extracellular space; lysosome; mitochondrial intermembrane space; mitochondrial matrix; mitochondrion; neuronal cell body; nucleoplasm; nucleus; peroxisome; plasma membrane; protein-containing complex

Molecular Function: chaperone binding; copper ion binding; identical protein binding; ion binding; protein binding; protein phosphatase 2B binding; small GTPase binding; superoxide dismutase activity; zinc ion binding

Biological Process: aging; anterograde axonal transport; apoptotic process; auditory receptor cell stereocilium organization; cellular iron ion homeostasis; cellular response to ATP; cellular response to cadmium ion; cellular response to potassium ion; ectopic germ cell programmed cell death; embryo implantation; glutathione metabolic process; heart contraction; hydrogen peroxide biosynthetic process; locomotory behavior; muscle cell cellular homeostasis; myeloid cell homeostasis; negative regulation of cholesterol biosynthetic process; negative regulation of developmental process; negative regulation of inflammatory response; negative regulation of neuron apoptotic process; negative regulation of reproductive process; neurofilament cytoskeleton organization; ovarian follicle development; peripheral nervous system myelin maintenance; placenta development; positive regulation of apoptotic process; positive regulation of catalytic activity; positive regulation of cytokine production; positive regulation of MAPK cascade; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; positive regulation of phagocytosis; positive regulation of superoxide anion generation; reactive oxygen species metabolic process; regulation of blood pressure; regulation of GTPase activity; regulation of mitochondrial membrane potential; regulation of multicellular organism growth; regulation of organ growth; regulation of protein kinase activity; regulation of T cell differentiation in thymus; relaxation of vascular associated smooth muscle; removal of superoxide radicals; response to amphetamine; response to antibiotic; response to antipsychotic drug; response to axon injury; response to carbon monoxide; response to copper ion; response to ethanol; response to heat; response to hydrogen peroxide; response to nutrient levels; response to organic substance; response to superoxide; response to xenobiotic stimulus; retina homeostasis; retrograde axonal transport; sensory perception of sound; spermatogenesis; superoxide anion generation; superoxide metabolic process; thymus development; transmission of nerve impulse

Disease: Amyotrophic Lateral Sclerosis 1; Spastic Tetraplegia And Axial Hypotonia, Progressive

Reference #: P00441 (UniProtKB)

Alt. Names/Synonyms: ALS; ALS1; Cu/Zn superoxide dismutase; epididymis secretory protein Li 44; HEL-S-44; homodimer; hSod1; indophenoloxidase A; IPOA; SOD; SOD, soluble; SOD1; SODC; STAHP; superoxide dismutase; Superoxide dismutase 1; superoxide dismutase 1, soluble; Superoxide dismutase [Cu-Zn]; superoxide dismutase, cystolic

Gene Symbols: SOD1

Molecular weight: 15,936 Da

Basal Isoelectric point: 5.7 Predict pI for various phosphorylation states

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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SOD1

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