GPLD1 This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane. Belongs to the GPLD1 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Phospholipase; Secreted; Secreted, signal peptide
Cellular Component:  cytoplasm; extracellular matrix; extracellular space; high-density lipoprotein particle; intracellular membrane-bounded organelle
Molecular Function:  glycosylphosphatidylinositol phospholipase D activity; sodium channel regulator activity
Biological Process:  cell migration involved in sprouting angiogenesis; cellular response to calcium ion; cellular response to cholesterol; cellular response to drug; cellular response to insulin stimulus; cellular response to pH; cellular response to triglyceride; chondrocyte differentiation; complement receptor mediated signaling pathway; GPI anchor release; insulin receptor signaling pathway; negative regulation of cell proliferation; negative regulation of triglyceride catabolic process; ossification; phosphatidylcholine metabolic process; positive regulation of alkaline phosphatase activity; positive regulation of apoptotic process; positive regulation of cytolysis; positive regulation of endothelial cell migration; positive regulation of glucose metabolic process; positive regulation of high-density lipoprotein particle clearance; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of membrane protein ectodomain proteolysis; positive regulation of secretion; positive regulation of triglyceride biosynthetic process; regulation of cellular response to insulin stimulus; response to glucose; transepithelial transport
Reference #:  P80109 (UniProtKB)
Alt. Names/Synonyms: BOS_21856; glycoprotein phospholipase D; glycosyl-phosphatidylinositol-specific phospholipase D; GPLD1; PHLD; Phosphatidylinositol-glycan-specific phospholipase D; PI-G PLD; PIGPLD
Gene Symbols: GPLD1
Molecular weight: 92,602 Da
Basal Isoelectric point: 6.17  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene