NRARP
Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal. Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis. During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD) and downregulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain. Belongs to the NRARP family. Note: This description may include information from UniProtKB.
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Protein type: Cell development/differentiation |
Chromosomal Location of human Ortholog: 9q34.3 |
Cellular Component:
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Molecular Function:
protein binding
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Biological Process:
blood vessel endothelial cell proliferation involved in sprouting angiogenesis; branching involved in blood vessel morphogenesis; negative regulation of Notch signaling pathway; negative regulation of Notch signaling pathway involved in somitogenesis; negative regulation of T cell differentiation; negative regulation of transcription by RNA polymerase II; Notch signaling pathway; positive regulation of canonical Wnt signaling pathway; positive regulation of endothelial cell proliferation; positive regulation of vascular endothelial cell proliferation; somite rostral/caudal axis specification; T cell differentiation; vascular endothelial cell proliferation
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Reference #:
Q7Z6K4
(UniProtKB)
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Alt. Names/Synonyms: MGC61598; NOTCH regulated ankyrin repeat protein; NOTCH-regulated ankyrin repeat protein; Notch-regulated ankyrin repeat-containing protein; NRARP
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Gene Symbols: NRARP
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Molecular weight:
12,492 Da
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Basal Isoelectric point:
6.82
Predict pI for various phosphorylation states
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