EGFR Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Plays a role in enhancing learning and memory performance. Isoform 2 may act as an antagonist of EGF action. (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; EGFR family; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of mouse Ortholog: 11 A2|11 9.41 cM
Cellular Component:  apical plasma membrane; basal plasma membrane; basolateral plasma membrane; cell junction; cell surface; cytoplasm; early endosome membrane; endocytic vesicle; endoplasmic reticulum; endosome; endosome membrane; Golgi apparatus; intracellular anatomical structure; intracellular vesicle; membrane; membrane raft; multivesicular body, internal vesicle lumen; nucleus; perinuclear region of cytoplasm; plasma membrane; protein-containing complex; receptor complex; ruffle membrane; synapse
Molecular Function:  actin filament binding; ATP binding; calmodulin binding; chromatin binding; enzyme binding; epidermal growth factor binding; epidermal growth factor receptor activity; identical protein binding; integrin binding; kinase activity; kinase binding; molecular function activator activity; nitric-oxide synthase regulator activity; nucleotide binding; phospholipase activator activity; protein binding; protein kinase activity; protein kinase binding; protein phosphatase binding; protein tyrosine kinase activator activity; protein tyrosine kinase activity; protein tyrosine phosphatase activator activity; protein-containing complex binding; signaling receptor binding; transferase activity; transmembrane receptor protein tyrosine kinase activator activity; transmembrane receptor protein tyrosine kinase activity; transmembrane signaling receptor activity; ubiquitin protein ligase binding
Biological Process:  astrocyte activation; cell differentiation; cell morphogenesis; cell population proliferation; cell surface receptor signaling pathway; cell-cell adhesion; cellular response to amino acid stimulus; cellular response to cadmium ion; cellular response to epidermal growth factor stimulus; cellular response to estradiol stimulus; cellular response to growth factor stimulus; cellular response to reactive oxygen species; cerebral cortex cell migration; digestive tract morphogenesis; embryonic placenta development; epidermal growth factor receptor signaling pathway; epidermis development; epithelial cell proliferation; ERBB2-EGFR signaling pathway; eyelid development in camera-type eye; hair follicle development; intracellular signal transduction; learning or memory; liver regeneration; magnesium ion homeostasis; morphogenesis of an epithelial fold; multicellular organism development; negative regulation of apoptotic process; negative regulation of cardiocyte differentiation; negative regulation of mitotic cell cycle; negative regulation of protein catabolic process; neuron projection morphogenesis; ovulation cycle; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of bone resorption; positive regulation of canonical Wnt signaling pathway; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of DNA repair; positive regulation of DNA replication; positive regulation of DNA-templated transcription; positive regulation of epithelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast proliferation; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of glial cell proliferation; positive regulation of inflammatory response; positive regulation of kinase activity; positive regulation of MAP kinase activity; positive regulation of MAPK cascade; positive regulation of miRNA maturation; positive regulation of mucus secretion; positive regulation of NIK/NF-kappaB signaling; positive regulation of nitric oxide mediated signal transduction; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphorylation; positive regulation of prolactin secretion; positive regulation of protein kinase B signaling; positive regulation of protein kinase C activity; positive regulation of protein localization to plasma membrane; positive regulation of protein phosphorylation; positive regulation of smooth muscle cell proliferation; positive regulation of superoxide anion generation; positive regulation of synaptic transmission, glutamatergic; positive regulation of transcription by RNA polymerase II; positive regulation of vasoconstriction; protein autophosphorylation; protein phosphorylation; regulation of cell population proliferation; regulation of ERK1 and ERK2 cascade; regulation of JNK cascade; regulation of nitric-oxide synthase activity; regulation of peptidyl-tyrosine phosphorylation; regulation of phosphatidylinositol 3-kinase signaling; response to calcium ion; response to UV-A; salivary gland morphogenesis; signal transduction; translation; transmembrane receptor protein tyrosine kinase signaling pathway; vasodilation; wound healing
Reference #:  Q01279 (UniProtKB)
Alt. Names/Synonyms: 9030024J15Rik; AI552599; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; EGF receptor; Egfr; Epidermal growth factor receptor; Erb; Erbb; Err; Errb1; Errp; OTTMUSP00000005385; OTTMUSP00000005386; wa-2; wa2; Wa5; waved 2
Gene Symbols: Egfr
Molecular weight: 134,853 Da
Basal Isoelectric point: 6.46  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  ErbB/HER Signaling  |  IL6 Signaling  |  Phospholipase Signaling  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene