FEZF2 Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. May be involved in innate immunity. Belongs to the krueppel C2H2-type zinc-finger protein family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Cell development/differentiation; DNA-binding; Transcription factor
Chromosomal Location of human Ortholog: 3p14.2
Cellular Component:  nucleus
Molecular Function:  chromatin binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; metal ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Process:  axonal fasciculation; cell dedifferentiation; cerebral cortex GABAergic interneuron migration; commitment of neuronal cell to specific neuron type in forebrain; dendrite development; dentate gyrus development; forebrain anterior/posterior pattern specification; locomotory behavior; negative regulation of cell population proliferation; negative regulation of neuron differentiation; negative regulation of transcription by RNA polymerase II; neuron fate determination; positive regulation of neuron differentiation; positive regulation of transcription by RNA polymerase II; regulation of axon guidance; regulation of gene expression; regulation of neurogenesis
Reference #:  Q8TBJ5 (UniProtKB)
Alt. Names/Synonyms: FEZ; FEZ family zinc finger 2; Fez family zinc finger protein 2; FEZF2; FEZL; FKSG36; FLJ10142; Forebrain embryonic zinc finger-like protein 2; forebrain embryonic zinc finger-like protein 2; OTTHUMP00000213300; OTTHUMP00000213301; testis tissue sperm-binding protein Li 80P; TOF; ZFP312; Zinc finger protein 312; Zinc finger protein Fez-like; ZNF312
Gene Symbols: FEZF2
Molecular weight: 48,811 Da
Basal Isoelectric point: 9.52  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene