Oct8 Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3'). Belongs to the POU transcription factor family. Class-3 subfamily. Brain. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 2q12.1
Cellular Component:  nucleus
Molecular Function:  DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; HMG box domain binding; sequence-specific DNA binding
Biological Process:  central nervous system development; cerebral cortex radially oriented cell migration; chemical homeostasis; excretion; forebrain ventricular zone progenitor cell division; metanephric ascending thin limb development; metanephric DCT cell differentiation; metanephric loop of Henle development; metanephric macula densa development; metanephric thick ascending limb development; negative regulation of apoptotic process; negative regulation of transcription, DNA-templated; positive regulation of cell proliferation; positive regulation of gene expression; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated
Disease: Snijders Blok-fisher Syndrome
Reference #:  P20264 (UniProtKB)
Alt. Names/Synonyms: Brain-1; Brain-specific homeobox/POU domain protein 1; Brn-1; BRN1; Oct-8; Oct8; Octamer-binding protein 8; Octamer-binding transcription factor 8; OTF-8; OTF8; PO3F3; POU class 3 homeobox 3; POU domain, class 3, transcription factor 3; POU3F3; SNIBFIS
Gene Symbols: POU3F3
Molecular weight: 50,327 Da
Basal Isoelectric point: 7.51  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein