GABARAP Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Belongs to the ATG8 family. Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Autophagy; Microtubule-binding; Ubiquitin-like modifier; Vesicle
Chromosomal Location of human Ortholog: 17p13.1
Cellular Component:  actin cytoskeleton; autophagosome; autophagosome membrane; axoneme; cell body; cytoplasmic vesicle; cytosol; Golgi membrane; lysosome; microtubule; microtubule associated complex; perinuclear region of cytoplasm; plasma membrane; smooth endoplasmic reticulum; sperm midpiece
Molecular Function:  beta-tubulin binding; GABA receptor binding; microtubule binding; protein binding; ubiquitin protein ligase binding
Biological Process:  autophagosome maturation; chemical synaptic transmission; extrinsic apoptotic signaling pathway via death domain receptors; macroautophagy; microtubule cytoskeleton organization; protein targeting
Reference #:  O95166 (UniProtKB)
Alt. Names/Synonyms: ATG8A; epididymis secretory sperm binding protein; FLC3B; FLJ25768; GABA type A receptor-associated protein; GABA(A) receptor-associated protein; GABARAP; GABARAP-a; Gamma-aminobutyric acid receptor-associated protein; GBRAP; MGC120154; MGC120155; MM46
Gene Symbols: GABARAP
Molecular weight: 13,918 Da
Basal Isoelectric point: 8.73  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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GABARAP

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene