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STAT1
Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Belongs to the transcription factor STAT family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription factor |
| Chromosomal Location of mouse Ortholog: 1 C1.1|1 26.81 cM |
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Cellular Component:
axon; chromatin; cytoplasm; cytosol; dendrite; ISGF3 complex; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm; protein-containing complex; RNA polymerase II transcription regulator complex
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Molecular Function:
CCR5 chemokine receptor binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding; enzyme binding; histone acetyltransferase binding; histone binding; identical protein binding; nuclear receptor binding; promoter-specific chromatin binding; protein binding; protein homodimerization activity; protein phosphatase 2A binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; transcription coactivator binding; transcription corepressor binding; tumor necrosis factor receptor binding; ubiquitin-like protein ligase binding
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Biological Process:
activation of cysteine-type endopeptidase activity involved in apoptotic process; cell population proliferation; cellular response to cytokine stimulus; cellular response to interferon-beta; cellular response to lipopolysaccharide; cellular response to organic cyclic compound; cellular response to type II interferon; cytokine-mediated signaling pathway; defense response; defense response to virus; DNA-templated transcription; interleukin-27-mediated signaling pathway; interleukin-9-mediated signaling pathway; lipopolysaccharide-mediated signaling pathway; macrophage derived foam cell differentiation; negative regulation by virus of viral protein levels in host cell; negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of macrophage fusion; positive regulation of defense response to virus by host; positive regulation of DNA-templated transcription; positive regulation of erythrocyte differentiation; positive regulation of interferon-alpha production; positive regulation of transcription by RNA polymerase II; receptor signaling pathway via JAK-STAT; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; renal tubule development; response to bacterium; response to exogenous dsRNA; response to interferon-beta; response to lipopolysaccharide; response to peptide hormone; response to type I interferon; response to type II interferon; signal transduction; tumor necrosis factor-mediated signaling pathway; type I interferon-mediated signaling pathway; type II interferon-mediated signaling pathway
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Reference #:
P42225
(UniProtKB)
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Alt. Names/Synonyms: 2010005J02Rik; AA408197; Signal transducer and activator of transcription 1; Stat1
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Gene Symbols: Stat1
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Molecular weight:
87,197 Da
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Basal Isoelectric point:
5.42
Predict pI for various phosphorylation states
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CST Pathways:
ErbB/HER Signaling
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Growth And Differentiation Control by MAPKs
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IL6 Signaling
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Inhibition of Apoptosis
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Regulation of P38 MAPKs
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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