STAT3 Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity. Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1. Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation. May play an apoptotic role by transctivating BIRC5 expression under LEP activation. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion. Belongs to the transcription factor STAT family. Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor
Chromosomal Location of mouse Ortholog: 11 D|11 63.82 cM
Cellular Component:  chromatin; cytoplasm; cytosol; glutamatergic synapse; mitochondrial inner membrane; nucleoplasm; nucleus; plasma membrane; postsynaptic density; protein-containing complex; RNA polymerase II transcription regulator complex; Schaffer collateral - CA1 synapse; transcription regulator complex
Molecular Function:  CCR5 chemokine receptor binding; chromatin DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; identical protein binding; nuclear glucocorticoid receptor binding; nuclear receptor activity; primary miRNA binding; protein binding; protein dimerization activity; protein homodimerization activity; protein kinase binding; protein phosphatase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; RNA sequestering activity; sequence-specific DNA binding; signaling adaptor activity; signaling receptor binding; transcription cis-regulatory region binding
Biological Process:  acute-phase response; astrocyte differentiation; cell differentiation; cell population proliferation; cellular response to cytokine stimulus; cellular response to hormone stimulus; cellular response to interleukin-17; cellular response to leptin stimulus; cellular response to organic cyclic compound; cytokine-mediated signaling pathway; defense response; eating behavior; energy homeostasis; gene expression; glucose homeostasis; growth hormone receptor signaling pathway; growth hormone receptor signaling pathway via JAK-STAT; inflammatory response; interleukin-11-mediated signaling pathway; interleukin-15-mediated signaling pathway; interleukin-2-mediated signaling pathway; interleukin-6-mediated signaling pathway; interleukin-9-mediated signaling pathway; intracellular receptor signaling pathway; leptin-mediated signaling pathway; modulation of chemical synaptic transmission; mRNA transcription by RNA polymerase II; negative regulation of autophagy; negative regulation of cell population proliferation; negative regulation of gene expression; negative regulation of glycolytic process; negative regulation of hydrogen peroxide biosynthetic process; negative regulation of inflammatory response; negative regulation of inflammatory response to wounding; negative regulation of neuron migration; negative regulation of primary miRNA processing; negative regulation of stem cell differentiation; phosphatidylinositol 3-kinase signaling; phosphorylation; positive regulation of angiogenesis; positive regulation of ATP biosynthetic process; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of cytokine production involved in inflammatory response; positive regulation of DNA-templated transcription; positive regulation of erythrocyte differentiation; positive regulation of gene expression; positive regulation of growth factor dependent skeletal muscle satellite cell proliferation; positive regulation of interleukin-1 beta production; positive regulation of interleukin-10 production; positive regulation of interleukin-6 production; positive regulation of interleukin-8 production; positive regulation of metalloendopeptidase activity; positive regulation of miRNA transcription; positive regulation of NF-kappaB transcription factor activity; positive regulation of Notch signaling pathway; positive regulation of transcription by RNA polymerase II; positive regulation of tumor necrosis factor production; positive regulation of vascular endothelial cell proliferation; postsynapse to nucleus signaling pathway; protein import into nucleus; radial glial cell differentiation; receptor signaling pathway via JAK-STAT; regulation of cell cycle; regulation of cell population proliferation; regulation of cellular response to hypoxia; regulation of DNA-templated transcription; regulation of feeding behavior; regulation of mitochondrial membrane permeability; regulation of multicellular organism growth; regulation of transcription by RNA polymerase II; response to cytokine; response to estradiol; response to ischemia; response to leptin; response to peptide hormone; retinal rod cell differentiation; sexual reproduction; signal transduction; somatic stem cell population maintenance; T-helper 17 cell lineage commitment; T-helper 17 type immune response; temperature homeostasis; transcription by RNA polymerase II; transforming growth factor beta receptor signaling pathway
Reference #:  P42227 (UniProtKB)
Alt. Names/Synonyms: 1110034C02Rik; acute phase response factor; Acute-phase response factor; Aprf; AW109958; OTTMUSP00000002052; OTTMUSP00000002053; Signal transducer and activator of transcription 3; Stat3
Gene Symbols: Stat3
Molecular weight: 88,054 Da
Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Microtubule Dynamics  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA