STAT5A Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation. Belongs to the transcription factor STAT family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor
Chromosomal Location of mouse Ortholog: 11 D|11 63.77 cM
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; double-stranded DNA binding; phosphate ion binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding
Biological Process:  activated T cell proliferation; B cell differentiation; cell population proliferation; cellular response to cytokine stimulus; cellular response to granulocyte macrophage colony-stimulating factor stimulus; cellular response to organic cyclic compound; cytokine-mediated signaling pathway; defense response; development of secondary female sexual characteristics; development of secondary male sexual characteristics; eosinophil differentiation; epithelial cell differentiation involved in prostate gland development; erythrocyte differentiation; female pregnancy; gamma-delta T cell differentiation; growth hormone receptor signaling pathway via JAK-STAT; interleukin-15-mediated signaling pathway; interleukin-2 production; interleukin-2-mediated signaling pathway; interleukin-3-mediated signaling pathway; interleukin-4-mediated signaling pathway; interleukin-5-mediated signaling pathway; interleukin-9-mediated signaling pathway; lactation; lipid storage; luteinization; lymphocyte differentiation; mammary gland development; mammary gland epithelium development; mammary gland involution; mast cell apoptotic process; mast cell differentiation; mast cell proliferation; mitotic cell cycle; myeloid cell apoptotic process; natural killer cell differentiation; natural killer cell mediated cytotoxicity; negative regulation of erythrocyte differentiation; negative regulation of mast cell apoptotic process; negative regulation of myeloid cell apoptotic process; peptidyl-tyrosine phosphorylation; Peyer's patch development; positive regulation of activated T cell proliferation; positive regulation of B cell differentiation; positive regulation of blood vessel endothelial cell migration; positive regulation of cell population proliferation; positive regulation of endothelial cell proliferation; positive regulation of gamma-delta T cell differentiation; positive regulation of inflammatory response; positive regulation of interleukin-2 production; positive regulation of lymphocyte differentiation; positive regulation of mast cell differentiation; positive regulation of mast cell proliferation; positive regulation of mitotic cell cycle; positive regulation of multicellular organism growth; positive regulation of natural killer cell differentiation; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of T cell proliferation; positive regulation of transcription by RNA polymerase II; prostate gland epithelium morphogenesis; receptor signaling pathway via JAK-STAT; reelin-mediated signaling pathway; regulation of cell adhesion; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of epithelial cell differentiation; regulation of multicellular organism growth; regulation of steroid metabolic process; regulation of transcription by RNA polymerase II; response to peptide hormone; signal transduction; T cell differentiation in thymus; T cell homeostasis; T cell proliferation; taurine metabolic process; transcription by RNA polymerase II
Reference #:  P42230 (UniProtKB)
Alt. Names/Synonyms: AA959963; Mammary gland factor; mammary gland factor STAT5A; Mgf; Mpf; OTTMUSP00000002045; OTTMUSP00000002046; RP23-279L23.4; Signal transducer and activator of transcription 5A; STA; STA5A; STAT5; Stat5a
Gene Symbols: Stat5a
Molecular weight: 90,831 Da
Basal Isoelectric point: 5.98  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  IL6 Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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STAT5A

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein