AKAP6 Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 6q23
Cellular Component:  calcium channel complex; caveola; cytoplasm; intercalated disc; junctional sarcoplasmic reticulum membrane; nuclear envelope; nuclear membrane; nucleus; perinuclear region of cytoplasm; protein-containing complex; sarcolemma; sarcoplasmic reticulum; T-tubule
Molecular Function:  adenylate cyclase binding; enzyme binding; ion channel binding; kinase activity; molecular adaptor activity; protein binding; protein kinase A binding; protein kinase A regulatory subunit binding; protein membrane anchor; protein phosphatase 2A binding
Biological Process:  cellular protein-containing complex localization; cellular response to cAMP; cellular response to cytokine stimulus; cellular response to epinephrine stimulus; negative regulation of adenylate cyclase activity; phosphorylation; positive regulation of calcineurin-NFAT signaling cascade; positive regulation of cAMP-dependent protein kinase activity; positive regulation of cell growth; positive regulation of cell growth involved in cardiac muscle cell development; positive regulation of delayed rectifier potassium channel activity; positive regulation of potassium ion transmembrane transport; positive regulation of protein phosphorylation; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of ryanodine-sensitive calcium-release channel activity; positive regulation of translation; regulation of cardiac muscle cell contraction; regulation of membrane repolarization; regulation of protein kinase A signaling; regulation of relaxation of cardiac muscle; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
Reference #:  Q9WVC7 (UniProtKB)
Alt. Names/Synonyms: A kinase (PRKA) anchor protein 6; A-kinase anchor protein 6; AKAP-6; Akap6; mAKAP; PRKA6; Protein kinase A-anchoring protein 6
Gene Symbols: Akap6
Molecular weight: 254,352 Da
Basal Isoelectric point: 4.95  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene