AKAP6 Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 6q23
Cellular Component:  caveola; cytoplasm; nuclear envelope; nuclear membrane; nuclear outer membrane; nucleus; perinuclear region of cytoplasm; protein complex; sarcolemma; sarcoplasmic reticulum; T-tubule
Molecular Function:  adenylate cyclase binding; enzyme binding; kinase activity; protein anchor; protein binding; protein complex scaffold activity; protein kinase A binding; protein N-terminus binding; protein phosphatase 2A binding
Biological Process:  negative regulation of cAMP biosynthetic process; phosphorylation; positive regulation of cell growth; positive regulation of phosphoprotein phosphatase activity; positive regulation of protein phosphorylation; positive regulation of release of sequestered calcium ion into cytosol
Reference #:  Q9WVC7 (UniProtKB)
Alt. Names/Synonyms: A kinase (PRKA) anchor protein 6; A-kinase anchor protein 6; AKAP-6; Akap6; mAKAP; PRKA6; Protein kinase A-anchoring protein 6
Gene Symbols: Akap6
Molecular weight: 254,352 Da
Basal Isoelectric point: 4.95  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene