AKAP6
Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes. Highly expressed in cardiac and skeletal muscle, followed by brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Adaptor/scaffold |
Chromosomal Location of rat Ortholog: 6q23 |
Cellular Component:
calcium channel complex; caveola; cytoplasm; intercalated disc; junctional sarcoplasmic reticulum membrane; nuclear envelope; nuclear membrane; nucleus; perinuclear region of cytoplasm; protein-containing complex; sarcolemma; sarcoplasmic reticulum; T-tubule
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Molecular Function:
adenylate cyclase binding; enzyme binding; molecular adaptor activity; protein binding; protein kinase A binding; protein kinase A regulatory subunit binding; protein phosphatase 2A binding; protein-membrane adaptor activity; transmembrane transporter binding
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Biological Process:
cellular response to cAMP; cellular response to cytokine stimulus; cellular response to epinephrine stimulus; negative regulation of adenylate cyclase activity; positive regulation of calcineurin-NFAT signaling cascade; positive regulation of cAMP-dependent protein kinase activity; positive regulation of cell growth; positive regulation of cell growth involved in cardiac muscle cell development; positive regulation of delayed rectifier potassium channel activity; positive regulation of potassium ion transmembrane transport; positive regulation of protein phosphorylation; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of ryanodine-sensitive calcium-release channel activity; positive regulation of translation; protein-containing complex localization; regulation of cardiac muscle cell contraction; regulation of membrane repolarization; regulation of protein kinase A signaling; regulation of relaxation of cardiac muscle; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
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Reference #:
Q9WVC7
(UniProtKB)
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Alt. Names/Synonyms: A kinase (PRKA) anchor protein 6; A-kinase anchor protein 6; AKAP-6; Akap6; mAKAP; PRKA6; Protein kinase A-anchoring protein 6
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Gene Symbols: Akap6
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Molecular weight:
254,352 Da
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Basal Isoelectric point:
4.95
Predict pI for various phosphorylation states
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