STAT6 Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling. Belongs to the transcription factor STAT family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 10 D3|10 74.59 cM
Cellular Component:  cytoplasm; cytosol; membrane raft; nuclear chromatin; nuclear membrane; nucleoplasm; nucleus
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; identical protein binding; protein binding; protein phosphatase binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding
Biological Process:  cellular response to hydrogen peroxide; cellular response to reactive nitrogen species; cytokine-mediated signaling pathway; defense response; interleukin-4-mediated signaling pathway; JAK-STAT cascade; JAK-STAT cascade involved in growth hormone signaling pathway; mammary gland epithelial cell proliferation; mammary gland morphogenesis; negative regulation of transcription by RNA polymerase II; negative regulation of type 2 immune response; positive regulation of cold-induced thermogenesis; positive regulation of isotype switching to IgE isotypes; positive regulation of transcription by RNA polymerase II; regulation of cell proliferation; regulation of transcription, DNA-templated; response to cytokine; response to peptide hormone; signal transduction; T-helper 1 cell lineage commitment
Reference #:  P52633 (UniProtKB)
Alt. Names/Synonyms: signal transducer and activator of transcription 6; Signal transducer and transcription activator 6; Stat6
Gene Symbols: Stat6
Molecular weight: 93,497 Da
Basal Isoelectric point: 5.87  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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STAT6

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene