PHB Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging. Belongs to the prohibitin family. Widely expressed in different tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Cell cycle regulation; Chaperone; Mitochondrial; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor
Chromosomal Location of rat Ortholog: 10q26
Cellular Component:  cell surface; cytoplasm; early endosome; extrinsic component of mitochondrial outer membrane; extrinsic component of presynaptic active zone membrane; GABA-ergic synapse; glutamatergic synapse; integral component of plasma membrane; mitochondrial crista; mitochondrial inner membrane; mitochondrion; nucleoplasm; nucleus; plasma membrane; postsynaptic density
Molecular Function:  complement component C3a binding; complement component C3b binding; DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding; histone deacetylase binding; protein C-terminus binding; proteinase activated receptor binding; transcription regulatory region DNA binding
Biological Process:  animal organ regeneration; cellular response to interleukin-6; DNA biosynthetic process; histone deacetylation; mitochondrion organization; negative regulation of androgen receptor signaling pathway; negative regulation of apoptotic process; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of ERK1 and ERK2 cascade; negative regulation of glucocorticoid receptor signaling pathway; negative regulation of protein catabolic process; negative regulation of transcription by competitive promoter binding; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; ovarian follicle atresia; ovarian follicle development; positive regulation of cell death; positive regulation of complement activation; positive regulation of ERK1 and ERK2 cascade; positive regulation of G protein-coupled receptor signaling pathway; positive regulation of gene expression; positive regulation of transcription, DNA-templated; progesterone receptor signaling pathway; protein stabilization; regulation of transcription, DNA-templated; response to cytokine; response to drug; response to ethanol; response to immobilization stress; response to peptide hormone
Reference #:  P67779 (UniProtKB)
Alt. Names/Synonyms: Phb; Prohibitin
Gene Symbols: Phb
Molecular weight: 29,820 Da
Basal Isoelectric point: 5.57  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  NURSA