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SEC62
Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER). Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides. Targets and properly positions newly synthesized presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen. Belongs to the SEC62 family. Note: This description may include information from UniProtKB.
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| Protein type: Channel, misc.; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of human Ortholog: 3q26.2 |
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Cellular Component:
endoplasmic reticulum; endoplasmic reticulum membrane; membrane; rough endoplasmic reticulum
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Molecular Function:
signaling receptor activity
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Biological Process:
cotranslational protein targeting to membrane; post-translational protein targeting to endoplasmic reticulum membrane; post-translational protein targeting to membrane, translocation
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Reference #:
Q99442
(UniProtKB)
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Alt. Names/Synonyms: Dtrp1; FLJ32803; hTP-1; HTP1; membrane protein SEC62, S.cerevisiae, homolog of; SEC62; SEC62 homolog (S. cerevisiae); SEC62 homolog, preprotein translocation factor; SEC62 preprotein translocation factor; TLOC1; TP-1; Translocation protein 1; Translocation protein SEC62
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Gene Symbols: SEC62
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Molecular weight:
45,862 Da
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Basal Isoelectric point:
6.67
Predict pI for various phosphorylation states
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